ReviewThe journal of headache and pain2019
Novel hypotheses emerging from GWAS in migraine?
Review in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Novel Potential Risk Loci for Migraine in the Portuguese Population.International journal of molecular sciences · 2026Article
- Article
- A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine.The journal of headache and pain · 2024Article
- Modulating oxidative stress and neurogenic inflammation: the role of topiramate in migraine treatment.Frontiers in aging neuroscience · 2024Review
- Integrating eQTL and GWAS data characterises established and identifies novel migraine risk loci.Human genetics · 2023Article
- Polygenic Contributions to Chronic Overlapping Pain Conditions in a Large Electronic Health Record Sample.The journal of pain · 2023Article
- Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity.Genetics · 2023Article
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Article
- A review of migraine genetics: gathering genomic and transcriptomic factors.Human genetics · 2022Review
- Prioritizing Suggestive Candidate Genes in Migraine: An Opinion.Frontiers in neurology · 2022Article
- Variability in oxidative stress-related genes (Frontiers in neurology · 2022Article
- Screening for Copy Number Variations of the 15q13.3 Hotspot inCurrent issues in molecular biology · 2021Article
- Phenome-wide analysis highlights putative causal relationships between self-reported migraine and other complex traits.The journal of headache and pain · 2021Article
- Structural and Functional Brain Changes in Migraine.Pain and therapy · 2021Review
- Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A>G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine.Journal of molecular neuroscience : MN · 2021Article
- Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine.Frontiers in neuroscience · 2021Article
- Management of Menstrual Migraine.Current neurology and neuroscience reports · 2020Review
- Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare.The journal of headache and pain · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent technical advances in genetics made large-scale genome-wide association studies (GWAS) in migraine feasible and have identified over 40 common DNA sequence variants that affect risk for migraine types. Most of the variants, which are all single nucleotide polymorphisms (SNPs), show robust association with migraine as evidenced by the fact that the vast majority replicate in subsequent independent studies. However, despite thorough bioinformatic efforts aimed at linking the migraine risk SNPs with genes and their molecular pathways, there remains quite some discussion as to how successful this endeavour has been, and their current practical use for the diagnosis and treatment of migraine patients. Although existing genetic information seems to favour involvement of vascular mechanisms, but also neuronal and other mechanisms such as metal ion homeostasis and neuronal migration, the complexity of the underlying genetic pathophysiology presents challenges to advancing genetic knowledge to clinical use. A major issue is to what extent one can rely on bioinformatics to pinpoint the actual disease genes, and from this the linked pathways. In this Commentary, we will provide an overview of findings from GWAS in migraine, current hypotheses of the disease pathways that emerged from these findings, and some of the major drawbacks of the approaches used to identify the genes and pathways. We argue that more functional research is urgently needed to turn the hypotheses that emerge from GWAS in migraine to clinically useful information.
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