Evidence map›Paper›PMID 30634897›Full record

ArticleBMC bioinformatics2019

MS-Helios: a Circos wrapper to visualize multi-omic datasets.

Harald Marx, Joshua J Coon

Abstract read
In one paragraph

Article in BMC bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Harald MarxDepartment of Microbiology and Ecosystems Science, University of Vienna, 1090, Vienna, Austria. harald.marx@wisc.edu.
Joshua J CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. jcoon@chem.wisc.edu.

Funding

TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Structure, Function and Regulation of the ProteomeR35GM118110 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$9.1M
National Institutes of Health P41 GM108538National Science Foundation DBI 0701846NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM118110
6 · The paper itself

Abstract

backgroundAdvances in high-resolution mass spectrometry facilitate the identification of hundreds of metabolites, thousands of proteins and their post-translational modifications. This remarkable progress poses a challenge to data analysis and visualization, requiring methods to reduce dimensionality and represent the data in a compact way. To provide a more holistic view, we recently introduced circular proteome maps (CPMs). However, the CPM construction requires prior data transformation and extensive knowledge of the Perl-based tool, Circos.

resultsWe present MS-Helios, an easy to use command line tool with multiple built-in data processing functions, allowing non-expert users to construct CPMs or in general terms circular plots with a non-genomic basis. MS-Helios automatically generates data and configuration files to create high quality and publishable circular plots with Circos. We showcase the software on large-scale multi-omic datasets to visualize global trends and/or to contextualize specific features.

conclusionsMS-Helios provides the means to easily map and visualize multi-omic data in a comprehensive way. The software, datasets, source code, and tutorial are available at https://sourceforge.net/projects/ms-helios/ .

Indexed as

Computer GraphicsSoftwareTranscriptomeAnimalsDatabases, FactualDatasets as TopicMass SpectrometryProgramming LanguagesProteomeSwineProteome

Identifiers

PMID30634897
PMCPMC6330434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.