ReviewMolecules (Basel, Switzerland)2019
Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review.
Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Review
- Inversion Motion of Xanthene and Detection of Its Oxidation Product Xanthone from Gas-Phase Rotational Spectroscopy.Molecules (Basel, Switzerland) · 2025Article
- Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis.Science advances · 2025Article
- Molecular modelling and experimental validation of mangiferin and its related compounds as quorum sensing modulators of Pseudomonas aeruginosa.Archives of microbiology · 2025Article
- The Chemical Space of Marine Antibacterials: Diphenyl Ethers, Benzophenones, Xanthones, and Anthraquinones.Molecules (Basel, Switzerland) · 2023Article
- Article
- A Review on Bioactive Compounds from Marine-DerivedJournal of microbiology and biotechnology · 2022Review
- Marine-Derived Xanthone from 2010 to 2021: Isolation, Bioactivities and Total Synthesis.Marine drugs · 2022Review
- phytochemdb: a platform for virtual screening and computer-aided drug designing.Database : the journal of biological databases and curation · 2022Article
- Synthesis and in vitro assay of hydroxyxanthones as antioxidant and anticancer agents.Scientific reports · 2022Article
- Promising bioactive compounds from the marine environment and their potential effects on various diseases.Journal, genetic engineering & biotechnology · 2022Review
- Bioactive Marine Xanthones: A Review.Marine drugs · 2022Review
- Modelling and targeting mitochondrial protein tyrosine phosphatase 1: a computational approach.In silico pharmacology · 2022Article
- An Update on the Anticancer Activity of Xanthone Derivatives: A Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria.Antibiotics (Basel, Switzerland) · 2021Article
- Antibacterial Secondary Metabolites from Marine-Derived FungusAntibiotics (Basel, Switzerland) · 2021Article
- Characterisation of twelve newly synthesisedArhiv za higijenu rada i toksikologiju · 2021Article
- Analogue discovery of safer alternatives to HCQ and CQ drugs for SAR-CoV-2 by computational design.Computers in biology and medicine · 2021Article
- From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Marine organisms represent almost half of total biodiversity and are a very important source of new bioactive substances. Within the varied biological activities found in marine products, their antimicrobial activity is one of the most relevant. Infectious diseases are responsible for high levels of morbidity and mortality and many antimicrobials lose their effectiveness with time due to the development of resistance. These facts justify the high importance of finding new, effective and safe anti-infective agents. Among the variety of biological activities of marine xanthone derivatives, one that must be highlighted is their anti-infective properties. In this work, a literature review of marine xanthones with anti-infective activity, namely antibacterial, antifungal, antiparasitic and antiviral, is presented. Their structures, biological activity, sources and the methods used for bioactivity evaluation are described. The xanthone derivatives are grouped in three sets: xanthones, hydroxanthones and glycosylated derivatives. Moreover, molecular descriptors, biophysico-chemical properties, and pharmacokinetic parameters were calculated, and the chemical space occupied by marine xanthone derivatives is recognized. The chemical space was compared with marketed drugs and framed accordingly to the drug-likeness concept in order to profile the pharmacokinetic of anti-infective marine xanthone derivatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.