Evidence map›Paper›PMID 30634695›Full record

ArticleCells2019

A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance.

Megumi Tsukamoto, Miho Yamashita, Tsuyoshi Nishi, Hiroshi Nakagawa

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  7. Homozygous ofFrontiers in genetics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Megumi TsukamotoDepartment of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan. gr16801@isc.chubu.ac.jp.
Miho YamashitaDepartment of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan. fr15109-5214@sti.chubu.ac.jp.
Tsuyoshi NishiDepartment of Biomolecular Science and Regulation, Osaka University, Ibaraki, Osaka 567-0047, Japan. tnishi@sanken.osaka-u.ac.jp.
Hiroshi NakagawaDepartment of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan. hnakagaw@isc.chubu.ac.jp.ORCID 0000-0002-9697-164X
Chubu University · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes. In the present study, we focused on the human ABC transporter ABCC4 and one major non-synonymous SNP variant of the

Indexed as

Antineoplastic AgentsATP-Binding Cassette, Sub-Family C ProteinsDrug Resistance, NeoplasmHEK293 CellsHumansIrinotecanPolymorphism, Single NucleotideABCC4 protein, humanAntineoplastic AgentsATP-Binding Cassette, Sub-Family C ProteinsIrinotecanABCC4ATP-binding cassette (ABC) transporterMRP4SNP

Identifiers

PMID30634695
PMCPMC6356542
OpenAlexW2909778541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.