Evidence map›Paper›PMID 30634650›Full record

SynthesisInternational journal of molecular sciences2019

Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer's Disease (AD): A Systematic Review and Meta-Analysis.

Ted Kheng Siang Ng, Cyrus Su Hui Ho, Wilson Wai San Tam, Ee Heok Kua, Roger Chun-Man Ho

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 14 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 14 syntheses or guidelines pooled it, 395 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. The Effects ofNutrients · 2022
    Trial

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Ted Kheng Siang NgDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. ted.ng@duke-nus.edu.sg.
Cyrus Su Hui HoDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. su_hui_ho@nuhs.edu.sg.ORCID 0000-0002-7092-9566
Wilson Wai San TamAlice Lee School of Nursing, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. nurtwsw@nus.edu.sg.ORCID 0000-0003-0641-3060
Ee Heok KuaDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. pcmkeh@nus.edu.sg.
Roger Chun-Man HoDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. pcmrhcm@nus.edu.sg.ORCID 0000-0001-9629-4493
National University of Singapore · SGHuaibei Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Findings from previous studies reporting the levels of serum brain-derived neurotrophic factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI) have been conflicting. Hence, we performed a meta-analysis to examine the aggregate levels of serum BDNF in patients with AD and individuals with MCI, in comparison with healthy controls. Fifteen studies were included for the comparison between AD and healthy control (HC) (

Indexed as

Alzheimer DiseaseAnimalsBiomarkersBrain-Derived Neurotrophic FactorCase-Control StudiesCognitive DysfunctionCross-Sectional StudiesDisease ProgressionHumansPublication BiasBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorAlzheimer’s diseaseBDNFcognitionmeta-analysismeta-regressionmild cognitive impairmentsystematic review

Identifiers

PMID30634650
PMCPMC6358753
OpenAlexW2908750541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.