ArticleInternational journal of molecular sciences2019
Improved In Vitro Test Procedure for Full Assessment of the Cytocompatibility of Degradable Magnesium Based on ISO 10993-5/-12.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Osteosynthesis devices in absorbable Magnesium alloy in comparison to standard ones: a Systematic Review on effectiveness and safety.Acta bio-medica : Atenei Parmensis · 2021Pooled it
- MTA does not induce oxidative stress and apoptotic response, or calcium-related cellular stress and preserves extracellular matrix homeostasis.Molecular biology reports · 2026Article
- Cytotoxicity Assessment and Indentation Size Effect of Low-Cost Experimental Implant Alloys.ACS materials Au · 2026Article
- Molybdenum as a biodegradable bone implant material assessed by ISO 10993-5/-12-compliant cytocompatibility testing and transcriptomic profiling in a human osteoblast cell line.Scientific reports · 2026Article
- A conductive antibacterial composite film containing chopped fibers and ciprofloxacin loaded PCL particles for wound dressing application.Journal of materials science. Materials in medicine · 2026Article
- Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).Molecular biology reports · 2026Article
- Resiquimod-loaded MOF525 enables synergistic photodynamic therapy and immunotherapy for colorectal cancer.Nano convergence · 2026Article
- Black phosphorus-loaded mineralized UV-responsive chitosan hydrogel for enhanced osteogenesis and antibacterial activity.Regenerative biomaterials · 2026Article
- Three-dimensional cell sheet model improvesBioactive materials · 2025Article
- Article
- Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges.Biomedical engineering online · 2025Review
- Article
- Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications.Journal of functional biomaterials · 2024Article
- Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia.International journal of molecular sciences · 2024Article
- Scaffold design considerations for peripheral nerve regeneration.Journal of neural engineering · 2024Review
- Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview.International journal of molecular sciences · 2024Review
- Doping of casted silk fibroin membranes with extracellular vesicles for regenerative therapy: a proof of concept.Scientific reports · 2024Article
- The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human PathogenPharmaceuticals (Basel, Switzerland) · 2024Article
- The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes.Frontiers in bioengineering and biotechnology · 2024Article
- Influence of Lithium- and Zinc-Containing Bioactive Glasses on Pulpal Regeneration.European journal of dentistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and the related (micro-) milieu conditions pretend to strictly follow in vitro standards based on ISO 10993-5/-12. Thus, special adaptions for the testing of Mg materials are necessary, which have been described in a previous study from our group. Based on these adaptions, further developments of a test procedure allowing rapid and effective in vitro cytocompatibility analyses of Mg-based materials based on ISO 10993-5/-12 are necessary. The following study introduces a new two-step test scheme for rapid and effective testing of Mg. Specimens with different surface characteristics were produced by means of plasma electrolytic oxidation (PEO) using silicate-based and phosphate-based electrolytes. The test samples were evaluated for corrosion behavior, cytocompatibility and their mechanical and osteogenic properties. Thereby, two PEO ceramics could be identified for further in vivo evaluations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.