ArticleNutrients2019
Hypovitaminosis D: A Disease Marker in Hospitalized Very Old Persons at Risk of Malnutrition.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Vitamin D Status in Patients at the Department of Internal, Autoimmune, and Metabolic Diseases-A Descriptive Cross-Sectional Study.Biomedicines · 2025Article
- On-admission serum 25(OH)D level and mortality within one year in older patients.BMC geriatrics · 2024Article
- Hospital Length of Stay and Associated Factors in Adult Patients with Depression in Germany: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Vitamin D and COVID-19: where are we now?Postgraduate medicine · 2023Review
- Could vitamin D concentration be a marker of a long hospital stay in older adults patients?Frontiers in nutrition · 2023Article
- Comparison of Prognostic Value of 10 Biochemical Indices at Admission for Prediction Postoperative Myocardial Injury and Hospital Mortality in Patients with Osteoporotic Hip Fracture.Journal of clinical medicine · 2022Article
- Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.Journal of general internal medicine · 2022Article
- Relevance of vitamin DGene reports · 2021Review
- Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality.Trends in endocrinology and metabolism: TEM · 2020Review
- MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.European journal of endocrinology · 2020Review
- To D or not to D: vitamin D in hematopoietic cell transplantation.Bone marrow transplantation · 2020Review
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypovitaminosis D is a frequent condition in elderly subjects. Vitamin D adequacy is best determined by measurement of the 25-hydroxyvitamin D-25(OH)D-concentration in the serum. An inverse association exists between 25(OH)D and cardiovascular, infectious, glucose metabolism, cognitive disorders, and all-cause mortality. Whether 25(OH)D is a marker of organ diseases is still under debate. We aimed to investigate whether comorbidities were associated with serum 25(OH)D levels in geriatric inpatients.
methodsThis is a retrospective study, including 237 subjects consecutively admitted to an acute care geriatric unit, with available data of 25(OH)D serum concentrations. 25(OH)D serum levels were defined according to the following cutoffs: 50⁻30 ng/mL (125⁻75 nmol/L): optimal range; 30⁻20 ng/mL (75⁻50 nmol/L): insufficiency; 20⁻10 ng/mL (5⁻25 nmol/L): deficiency; and <10 ng/mL (<25 nmol/L): severe deficiency. Comorbidity was assessed using the Cumulative Illness Rating Scale-Geriatric (CIRS-G). Two summary measures were obtained, the Illness Severity Index (CIRS-SI) and the Comorbidity Index (CIRS-CI).
results177 (74.68%) women and 60 (25.32%) men with mean age of 85 ± 6 years old were enrolled. The majority of subjects (68.6%) were at risk of malnutrition. Overall, the burden of comorbidity was 1.87 ± 1.33 for CIRS-CI and 1.18 ± 0.40 for CIRS-SI. 25(OH)D serum concentrations were 10.58 ± 7.68 ng/mL, with 98.7% of subjects having vitamin D below 30 ng/mL and 56.6% with severe deficiency. An inverse correlation was found between 25(OH)D and both CIRS-SI (
conclusionsIn hospitalized very old subjects, a higher comorbidity burden is associated with lower 25(OH)D serum levels. Hypovitaminosis D was correlated with higher inflammatory status, which, together with the comorbidities burden, negatively influenced the length of hospital stay.
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