Evidence map›Paper›PMID 30634545›Full record

ArticleNutrients2019

Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy.

Eun-Jung Lee, Min-Kyung Kang, Yun-Ho Kim, Dong Yeon Kim, Hyeongjoo Oh, Soo-Il Kim, Su Yeon Oh, Young-Hee Kang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Anticancer Activity of Ether Derivatives of Chrysin.Molecules (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Mitophagy in Diabetic Kidney Disease.Frontiers in cell and developmental biology · 2021
    Review
  9. Review
  10. Article
  11. Chrysin ameliorates nonalcoholic fatty liver disease in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2019
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eun-Jung LeeDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. reydmswjd@naver.com.
Min-Kyung KangDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. mitholy@hallym.ac.kr.
Yun-Ho KimDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. royalskim@hallym.ac.kr.
Dong Yeon KimDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. ehddus3290@naver.com.
Hyeongjoo OhDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. ohhyeongju@gmail.com.
Soo-Il KimDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. ky4850@naver.com.
Su Yeon OhDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. suy0411@naver.com.
Young-Hee KangDepartment of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea. yhkang@hallym.ac.kr.
Hallym University · KR

Funding

Hallym University HRF-201810-008
6 · The paper itself

Abstract

Advanced glycation end products (AGE) play a causative role in the development of aberrant phenotypes of intraglomerular mesangial cells, contributing to acute/chronic glomerulonephritis. The aim of this study was to explore mechanistic effects of the flavonoid chrysin present in bee propolis and herbs on actin dynamics, focal adhesion, and the migration of AGE-exposed mesangial cells. The in vitro study cultured human mesangial cells exposed to 33 mM glucose and 100 μg/mL AGE-bovine serum albumin (AGE-BSA) for up to 5 days in the absence and presence of 1⁻20 μM chrysin. The in vivo study employed

Indexed as

AutophagyDiabetes Mellitus, ExperimentalActin CytoskeletonActinsAnimalsAutophagy-Related Protein 7Autophagy-Related ProteinsBeclin-1Carrier ProteinsCell LineCell MovementCortactinFlavonoidsFocal AdhesionsGlycation End Products, AdvancedHumansActinsATG3 protein, humanATG7 protein, humanAutophagy-Related Protein 7Autophagy-Related ProteinsBeclin-1Carrier ProteinschrysinCortactinCTTN protein, humanCttn protein, mousefascinFlavonoidsFSCN1 protein, humanGlycation End Products, AdvancedMicrofilament ProteinsTOR Serine-Threonine KinasesUbiquitin-Conjugating EnzymesVCL protein, humanVinculinactin cytoskeletonadvanced glycation end productsautophagychrysinfocal adhesionmesangial migration

Identifiers

PMID30634545
PMCPMC6705957
OpenAlexW2908733918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.