Evidence map›Paper›PMID 30634525›Full record

ArticleGenes2019

Using a Chemical Genetic Screen to Enhance Our Understanding of the Antimicrobial Properties of Gallium against Escherichia coli.

Natalie Gugala, Kate Chatfield-Reed, Raymond J Turner, Gordon Chua

Open access · goldAbstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. The good, the bad, and the ugly of metals as antimicrobials.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  4. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Experimental evolution of gallium resistance inEvolution, medicine, and public health · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Natalie GugalaDepartment of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. ngugala@ucalgary.ca.
Kate Chatfield-ReedSeidman Cancer Center, University Hospitals, 11100 Euclid Ave, Cleveland, OH 44106, USA. katherine.chatfield-reed@UHhospitals.org.
Raymond J TurnerDepartment of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. turnerr@ucalgary.ca.ORCID 0000-0002-9263-0776
Gordon ChuaDepartment of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. gchua@ucalgary.ca.
University of Calgary · CAUniversity Hospitals Seidman Cancer Center · US

Funding

CIHR PJT-149009
6 · The paper itself

Abstract

The diagnostic and therapeutic agent gallium offers multiple clinical and commercial uses including the treatment of cancer and the localization of tumors, among others. Further, this metal has been proven to be an effective antimicrobial agent against a number of microbes. Despite the latter, the fundamental mechanisms of gallium action have yet to be fully identified and understood. To further the development of this antimicrobial, it is imperative that we understand the mechanisms by which gallium interacts with cells. As a result, we screened the

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsEscherichia coliEscherichia coli ProteinsGalliumAnti-Bacterial AgentsEscherichia coli ProteinsGalliumantimicrobial agentsEscherichia coligalliummetal-based antimicrobialsmetal resistancemetal toxicity

Identifiers

PMID30634525
PMCPMC6356860
OpenAlexW2910017122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.