ArticleMedical science monitor : international medical journal of experimental and clinical research2019
The Role of Disturbed Small-World Networks in Patients with White Matter Lesions and Cognitive Impairment Revealed by Resting State Function Magnetic Resonance Images (rs-fMRI).
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Frontal, temporal, cerebellar changes link to sepsis survivors' cognitive issues: A resting state functional magnetic resonance imaging study.World journal of psychiatry · 2025Article
- Neuroimaging and molecular mechanism of action of Cang-ai volatile oil in the treatment of vascular cognitive impairment.Frontiers in neuroscience · 2025Article
- Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia.Frontiers in aging neuroscience · 2025Review
- A window into the brain: multimodal MRI assessment of vascular cognitive impairment.Frontiers in neuroscience · 2025Review
- Comparing the Efficacy of Two Cognitive Screening Tools in Identifying Gray and White Matter Brain Damage among Older Adults.Journal of aging research · 2024Article
- Observational
- A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment.Frontiers in neurology · 2023Review
- Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia.Frontiers in aging neuroscience · 2023Review
- Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities.Brain sciences · 2022Article
- Disrupted topological organization of resting-state functional brain networks in cerebral small vessel disease.Human brain mapping · 2022Article
- Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease.BMC medical imaging · 2022Article
- The Clustering Analysis of Time Properties in Patients With Cerebral Small Vessel Disease: A Dynamic Connectivity Study.Frontiers in neurology · 2022Article
- Association of Age and Structural Brain Changes With Functional Connectivity and Executive Function in a Middle-Aged to Older Population-Based Cohort.Frontiers in aging neuroscience · 2022Article
- Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity.Frontiers in aging neuroscience · 2021Article
- Disrupted Structural Brain Connectome Is Related to Cognitive Impairment in Patients With Ischemic Leukoaraiosis.Frontiers in human neuroscience · 2021Article
- Alterations in the whole brain network organization after prenatal ethanol exposure.The European journal of neuroscience · 2020Article
- The Application of rs-fMRI in Vascular Cognitive Impairment.Frontiers in neurology · 2020Review
- Effect and Neuroimaging Mechanism of Electroacupuncture for Vascular Cognitive Impairment No Dementia: Study Protocol for a Randomized, Assessor-Blind, Controlled Clinical Trial.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Impaired Structural Network Properties Caused by White Matter Hyperintensity Related to Cognitive Decline.Frontiers in neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Leukoaraiosis is characterized by white matter lesions (WMLs) on magnetic resonance imaging (MRI) and is associated with cognitive impairment. The small-world network is viewed as the optimal brain network with maximal efficiency in information processing. Patients with cognitive impairment are thought to have disrupted small-world networks. In this study, we compared the small-world network attributes between controls (study participants without memory complaints) and patients with WMLs with cognitive impairment. MATERIAL AND METHODS All study participants were prescreened using MRI and neuropsychological tests. Patients with WMLs were further divided into 2 groups according to the result of Montreal Cognitive Assessment (MoCA), i.e., WMLs with non-dementia vascular cognitive impairment (WMLs-VCIND) and WMLs with vascular dementia (WMLs-VaD). Resting-state functional MRI data were collected and applied with graph theoretical analysis to compare small-world properties between the 3 groups. RESULTS We found that the overall functional connectivity strength was lowest in the WMLs-VaD patients but highest in the normal control study participants. Patients in both the WMLs-VCIND and the WMLs-VaD groups had decreased small-world properties compared with the group of normal control study participants. Moreover, the small-world properties significantly correlated with MoCA scores. CONCLUSIONS These findings suggest potential constructive reorganization of brain networks secondary to WMLs, and provides novel insights into the role of small-world properties in cognitive dysfunction in WMLs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.