ArticlePharmacological research2019
Anti-hypertensive mechanisms of cyclic depsipeptide inhibitor ligands for G
Article in Pharmacological research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- PAR2 Regulates Cardiac Pressure and Vascular Function Through Context-Dependent Signalling Mechanisms.Current issues in molecular biology · 2026Article
- Comparative Evaluation of Vasorelaxant and Antiplatelet Activity of Two Plant-Derived Benzoquinones: Rapanone and Embelin.Molecules (Basel, Switzerland) · 2025Article
- Stabilization of interdomain closure by a G protein inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Bacterial GJournal of chemical ecology · 2023Article
- Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability.Synthesis · 2023Article
- Exploring pharmacological inhibition of GBritish journal of pharmacology · 2022Article
- Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues.Antioxidants (Basel, Switzerland) · 2022Review
- Maladaptation of renal hemodynamics contributes to kidney dysfunction resulting from thoracic spinal cord injury in mice.American journal of physiology. Renal physiology · 2022Article
- Capitalizing on Mediated Electrolyses for the Construction of Complex, Addressable Molecular Surfaces.The Journal of organic chemistry · 2021Article
- Targeted Isolation of a Cytotoxic Cyclic Hexadepsipeptide from the Mesophotic Zone Sponge-Associated FungusMarine drugs · 2021Article
- Functional evidence for biased inhibition of G protein signaling by YM-254890 in human coronary artery endothelial cells.European journal of pharmacology · 2021Article
- Sensitive LC-MS/MS Method for the Quantification of Macrocyclic GαFrontiers in chemistry · 2020Article
- Targeting primary and metastatic uveal melanoma with a G protein inhibitor.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper-stimulation of G protein couple receptors (GPCRs) and downstream signaling components. Although GPCR blockade is a key component of current anti-hypertensive strategies, whether hypertension is better managed by directly targeting G proteins has not been thoroughly investigated. Here, we tested whether inhibiting G
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.