ArticleExperimental gerontology2019
Age-related alterations in swallowing biomechanics.
Article in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Behavioral characterization of bulbar sensorimotor function in a rat model of Alexander disease.Behavioural brain research · 2026Article
- Review
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Oropharyngeal dysphagia and amyloid beta pathology in the TgF344-AD rat model of Alzheimer's disease.Frontiers in behavioral neuroscience · 2026Article
- Effects of Aging on Correlation of Striated Esophageal and Pharyngeal Deglutitive Motor Function.Gastroenterology research and practice · 2026Article
- Effects of chemoradiation and tongue exercise on swallow biomechanics and bolus kinematics.Head & neck · 2025Article
- Task-Based Eating and Drinking Interventions in Animal Models: A Narrative Review of Functional Improvements and Neuromuscular Adaptations in Age-Related Dysphagia.Geriatrics (Basel, Switzerland) · 2024Review
- Vocal and tongue exercise in early to mid-stage Parkinson disease using the Pink1-/- rat.Brain research · 2024Article
- Study on predictive models for swallowing risk in patients with AECOPD.BMC pulmonary medicine · 2024Article
- Biomechanical and Cortical Control of Tongue Movements During Chewing and Swallowing.Dysphagia · 2024Review
- [Multiple factors contributing to dysphagia : Extended tasks for the interprofessional team in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Article
- Presbyphagia: Dysphagia in the elderly.World journal of clinical cases · 2023Review
- Effects of thickened carbonated cola in older patients with dysphagia.Scientific reports · 2022Article
- A simplified method for evaluating swallowing ability and estimating malnutrition risk: A pilot study in older adults.PloS one · 2022Article
- Respiratory-swallow coordination in a rat model of chemoradiation.Head & neck · 2021Article
- Swallowing dysfunction following radiation to the rat mylohyoid muscle is associated with sensory neuron injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Effects of Tongue Exercise Frequency on Tongue Muscle Biology and Swallowing Physiology in a Rat Model.Dysphagia · 2020Article
- Myogenic marker expression as a function of age and exercise-based therapy in the tongue.Experimental gerontology · 2020Article
- Reduced tongue force and functional swallowing changes in a rat model of post stroke dysphagia.Brain research · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAging rodent models allow for the discovery of underlying mechanisms of cranial muscle dysfunction. Methods are needed to allow quantification of complex, multivariate biomechanical movements during swallowing. Videofluoroscopic swallow studies (VSS) are the standard of care in assessment of swallowing disorders in patients and validated quantitative, kinematic, and morphometric analysis methods have been developed. Our purpose was to adapt validated morphometric techniques to the rodent to computationally analyze swallowing dysfunction in the aging rodent.
methodsVSS, quantitative analyses (bolus area, bolus velocity, mastication rate) and a rodent specific multivariate, morphometric computational analysis of swallowing biomechanics were performed on 20 swallows from 5 young adult and 5 old Fischer 344/Brown Norway rats. Eight anatomical landmarks were used to track the relative change in position of skeletal levers (cranial base, vertebral column, mandible) and soft tissue landmarks (upper esophageal sphincter, base of tongue).
resultsBolus area significantly increased and mastication rate significantly decreased with age. Aging accounted for 77.1% of the variance in swallow biomechanics, and 18.7% of the variance was associated with swallow phase (oral vs pharyngeal). Post hoc analyses identified age-related alterations in tongue base retraction, mastication, and head posture during the swallow.
conclusionGeometric morphometric analysis of rodent swallows suggests that swallow biomechanics are altered with age. When used in combination with biological assays of age-related adaptations in neuromuscular systems, this multivariate analysis may increase our understanding of underlying musculoskeletal dysfunction that contributes to swallowing disorders with aging.
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