ArticleThe European journal of neuroscience2019
Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.
Article in The European journal of neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Timing and Convergence of Ensemble Activity Govern Auditory Thalamocortical Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Striatal cell-type-specific molecular signatures reveal potential therapeutic targets in a model of dystonia.Neurobiology of disease · 2025Article
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- Editorial: Reconfiguration of neuronal ensembles throughout learning.Frontiers in systems neuroscience · 2023Article
- Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging.PloS one · 2023Article
- Conceptual framework for neuronal ensemble identification and manipulation related to behavior using calcium imaging.Neurophotonics · 2022Review
- Striatal mechanisms of turning behaviour following unilateral dopamine depletion in mice.The European journal of neuroscience · 2022Article
- Translational neuronal ensembles: Neuronal microcircuits in psychology, physiology, pharmacology and pathology.Frontiers in systems neuroscience · 2022Review
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism.Frontiers in synaptic neuroscience · 2022Article
- Dimensionality reduction and recurrence analysis reveal hidden structures of striatal pathological states.Frontiers in systems neuroscience · 2022Article
- Experience-related enhancements in striatal temporal encoding.The European journal of neuroscience · 2021Article
- An Introspective Approach: A Lifetime of Parkinson's Disease Research and Not Much to Show for it Yet?Cells · 2021Article
- Synaptic Pruning by Microglia in Epilepsy.Journal of clinical medicine · 2019Review
- Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.The European journal of neuroscience · 2019Article
- Dopamine DASN neuroArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
For more than three decades it has been known, that striatal neurons become hyperactive after the loss of dopamine input, but the involvement of dopamine (DA) D1- or D2-receptor-expressing neurons has only been demonstrated indirectly. By recording neuronal activity using fluorescent calcium indicators in D1 or D2 eGFP-expressing mice, we showed that following dopamine depletion, both types of striatal output neurons are involved in the large increase in neuronal activity generating a characteristic cell assembly of particular neurons that dominate the pattern. When we expressed channelrhodopsin in all the output neurons, light activation in freely moving animals, caused turning like that following dopamine loss. However, if the light stimulation was patterned in pulses the animals circled in the other direction. To explore the neuronal participation during this stimulation we infected normal mice with channelrhodopsin and calcium indicator in striatal output neurons. In slices made from these animals, continuous light stimulation for 15 s induced many cells to be active together and a particular dominant group of neurons, whereas light in patterned pulses activated fewer cells in more variable groups. These results suggest that the simultaneous activity of a large dominant group of striatal output neurons is intimately associated with parkinsonian symptoms.
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Registered trials
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