ArticleTransfusion2019
Elevated risk for iron depletion in high-school age blood donors.
Article in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of iron repletion on brain iron content, myelination, neural network activation, and cognition.JCI insight · 2025Trial
- Trial
- Hemoglobinopathies and iron deficiency among Northeast-Thai blood donors deferred for low hemoglobin.Scientific reports · 2025Article
- Blood donor populations reveal a clear association between ferritin and change in haemoglobin levels.British journal of haematology · 2025Article
- Diagnostics: Markers of Body Iron Status.Advances in experimental medicine and biology · 2025Review
- Next generation sequencing to identify iron status and individualise blood donors' experience.Blood transfusion = Trasfusione del sangue · 2023Article
- Red Blood Cell Storage: From Genome to Exposome Towards Personalized Transfusion Medicine.Transfusion medicine reviews · 2023Review
- From Unit to Dose: A Machine Learning Approach for Precise Prediction of Hemoglobin and Iron Content in Individual Packed Red Blood Cell Units.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity.Haematologica · 2021Article
- Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- Supplemental findings of the 2017 National Blood Collection and Utilization Survey.Transfusion · 2020Article
- Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population.Transfusion · 2019Article
- Sociodemographic and behavioral characteristics associated with blood donation in the United States: a population-based study.Transfusion · 2019Article
- Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?Blood transfusion = Trasfusione del sangue · 2019Review
- Association of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative study.Transfusion · 2019Article
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundHigh school students 16 to 18 years-old contribute 10% of the US blood supply. Mitigating iron depletion in these donors is important because they continue to undergo physical and neurocognitive development. STUDY DESIGN AND
methodsStudy objectives were to determine the prevalence of iron depletion in 16- to 18-year-old donors and whether their risk for iron depletion was greater than adult donors. Successful, age-eligible donors were enrolled from high school blood drives at two large US blood centers. Plasma ferritin testing was performed with ferritin less than 12 ng/mL as our primary measure of iron depletion and ferritin less than 26 ng/mL a secondary measure. Multivariable repeated-measures logistic regression models evaluated the role of age and other demographic/donation factors.
resultsFerritin was measured from 4265 enrollment donations September to November 2015 and 1954 follow-up donations through May 2016. At enrollment, prevalence of ferritin less than 12 ng/mL in teenagers was 1% in males and 18% in females making their first blood donation, and 8% in males and 33% in females with prior donations. Adjusted odds for ferritin less than 12 ng/mL were 2.1 to 2.8 times greater in 16- to 18-year-olds than in 19- to 49-year-olds, and for ferritin less than 26 ng/mL were 3.3- to 4.7-fold higher in 16- to 18-year-olds. Progression to hemoglobin deferral was twice as likely in 16- to 18-year-old versus 19- to 49-year-old females.
conclusionAge 16 to 18 years-old is an independent risk factor for iron deficiency in blood donors at any donation frequency. Blood centers should implement alternate eligibility criteria or additional safety measures to protect teenage donors from iron depletion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.