ArticlePLoS biology2019
Resolving the apparent transmission paradox of African sleeping sickness.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions.Nature communications · 2026Article
- Evaluation of two candidate molecules-TCTP and cecropin-on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis.Insect science · 2025Article
- Dermal trypanosomes in seropositive suspects of gambiense human African trypanosomiasis in Côte d'Ivoire.PLoS neglected tropical diseases · 2025Observational
- Modelling timelines to elimination of sleeping sickness in the Democratic Republic of Congo, accounting for possible cryptic human and animal transmission.Parasites & vectors · 2024Article
- Prevalence of dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis in Guinea.PLoS neglected tropical diseases · 2024Observational
- The Hidden Hand of Asymptomatic Infection Hinders Control of Neglected Tropical Diseases: A Modeling Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms.Nature communications · 2023Article
- Does a One Health approach to human African trypanosomiasis control hasten elimination? A stochastic compartmental modeling approach.Acta tropica · 2023Article
- Impact of pulmonary African trypanosomes on the immunology and function of the lung.Nature communications · 2022Article
- SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis.EBioMedicine · 2022Article
- Modelling to infer the role of animals in gambiense human African trypanosomiasis transmission and elimination in the DRC.PLoS neglected tropical diseases · 2022Article
- Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal.Nature communications · 2022Article
- Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo.Nature communications · 2022Article
- Article
- Article
- Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.PLoS pathogens · 2021Review
- Modelling to explore the potential impact of asymptomatic human infections on transmission and dynamics of African sleeping sickness.PLoS computational biology · 2021Article
- Unexpected plasticity in the life cycle ofeLife · 2021Article
- Extravascular Dermal Trypanosomes in Suspected and Confirmed Cases of gambiense Human African Trypanosomiasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Observational
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
Abstract
Human African trypanosomiasis (HAT), or African sleeping sickness, is a fatal disease found throughout sub-Saharan Africa. The disease is close to elimination in many areas, although it was similarly close to elimination once before and subsequently reemerged, despite seemingly low rates of transmission. Determining how these foci persisted and overcame an apparent transmission paradox is key to finally eliminating HAT. By assessing clinical, laboratory, and mathematical data, we propose that asymptomatic infections contribute to transmission through the presence of an overlooked reservoir of skin-dwelling parasites. Our assessment suggests that a combination of asymptomatic and parasitaemic cases is sufficient to maintain transmission at foci without animal reservoirs, and we argue that the current policy not to treat asymptomatic HAT should be reconsidered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.