Evidence map›Paper›PMID 30633339›Full record

ArticleBiopolymers2019

Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions.

Christian J Jimenez, Jiacheng Tan, Kalli M Dowell, Gillian E Gadbois, Cameron A Read, Nicole Burgess, Jesus E Cervantes, Shannon Chan, Anmol Jandaur, Tara Karanik and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Biopolymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Christian J JimenezDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Jiacheng TanDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Kalli M DowellDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Gillian E GadboisDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Cameron A ReadDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Nicole BurgessDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Jesus E CervantesDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Shannon ChanDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Anmol JandaurDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Tara KaranikDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Jaenic J LeeDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Mikaela C LeyDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Molly McGeehanDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Ann McMonigalDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Kira L PalazzoDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Samantha A ParkerDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Andre PaymanDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Maritza SoriaDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Lauren VerheydenDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Vivian T VoDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Jennifer YinDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Anna L CalkinsDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.
Amelia A FullerDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.ORCID https://orcid.org/0000-0002-9291-6037
Grace Y StokesDepartment of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.ORCID https://orcid.org/0000-0002-5296-1853
Santa Clara University · US

Funding

Bastiani Research AwardCarl Gellert and Celia Berta Gellert FoundationHenry Luce Foundation, Clare Boothe Luce Professorship and Clare Boothe Luce Undergraduate Research FellowshipNational Science Foundation CHE-1566604Research Corporation for Scientific Advancement Cottrell Scholar AwardSanta Clara University
6 · The paper itself

Abstract

Peptoids are versatile peptidomimetic molecules with wide-ranging applications from drug discovery to materials science. An understanding of peptoid sequence features that contribute to both their three-dimensional structures and their interactions with lipids will expand functions of peptoids in varied fields. Furthermore, these topics capture the enthusiasm of undergraduate students who prepare and study diverse peptoids in laboratory coursework and/or in faculty led research. Here, we present the synthesis and study of 21 peptoids with varied functionality, including 19 tripeptoids and 2 longer oligomers. We observed differences in fluorescence spectral features for 10 of the tripeptoids that correlated with peptoid flexibility and relative positioning of chromophores. Interactions of representative peptoids with sonicated glycerophospholipid vesicles were also evaluated using fluorescence spectroscopy. We observed evidence of conformational changes effected by lipids for select peptoids. We also summarize our experiences engaging students in peptoid-based projects to advance both research and undergraduate educational objectives in parallel.

Indexed as

GlycerophospholipidsHydrogen-Ion ConcentrationMolecular ConformationPeptoidsSpectrometry, FluorescenceGlycerophospholipidsPeptoidschemistry educationfluorescence spectroscopypeptidomimeticsphospholipid membranessequence-structure relationships

Identifiers

PMID30633339
PMCPMC6590334
OpenAlexW2911147030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.