ArticleInvestigative radiology2019
Quantitative Multiparametric Breast Ultrasound: Application of Contrast-Enhanced Ultrasound and Elastography Leads to an Improved Differentiation of Benign and Malignant Lesions.
Article in Investigative radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Exploring shear-wave elastography and apparent diffusion coefficient in breast lesion characterization: diagnostic accuracy and inter-modality correlation.La Radiologia medica · 2026Article
- Development of a quantitative multiparametric ultrasound and deep learning classifier for the detection of prostate cancer.European radiology · 2026Article
- Can the new combined CEUS-BI-RADS score (CB score) reduce the number of breast false positive biopsies? Results from a monocentric study.La Radiologia medica · 2026Article
- Integrating morphology, vascularity, and elasticity: diagnostic role of multiparametric quantitative ultrasound in breast lesions.Journal of ultrasound · 2026Article
- A dual-core driven hybrid radiomics integrates multiple views of greyscale ultrasound image for the early management from diagnosis to biopsy suggestion of BI-RADS 4 breast lesions: a prospective multicenter study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- The application of multimodal ultrasound examination in the differential diagnosis of benign and malignant breast lesions of BI-RADS category 4.Frontiers in medicine · 2025Article
- Breast multiparametric ultrasound: a single-center experience.Journal of ultrasound · 2024Article
- Motion correction of 3D dynamic contrast-enhanced ultrasound imaging without anatomical B-Mode images: Pilot evaluation in eight patients.Medical physics · 2024Article
- Article
- Artificial intelligence-based, semi-automated segmentation for the extraction of ultrasound-derived radiomics features in breast cancer: a prospective multicenter study.La Radiologia medica · 2024Article
- Bibliometric and visualized analysis of reporting and data systems from 2000 to 2022: research situation, global trends, and hotspots.Quantitative imaging in medicine and surgery · 2024Article
- Development and Validation of a Nomogram for Predicting Breast Malignancy in Male Patients Based on Clinical and Ultrasound Features.Current radiopharmaceuticals · 2024Article
- Article
- Review
- Development and validation of a nomogram for discriminating between benign and malignant breast masses by conventional ultrasound and dual-mode elastography: a multicenter study.Quantitative imaging in medicine and surgery · 2023Article
- Article
- Influence of exercise on quantity and deformability of immune cells in multiple sclerosis.Frontiers in neurology · 2023Article
- Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease.Frontiers in endocrinology · 2023Article
- The clinical value of conventional ultrasound combined with contrast-enhanced ultrasound in the evaluation of BI-RADS 4 lesions detected by magnetic resonance imaging.The British journal of radiology · 2022Article
- Contrast-enhanced ultrasound of breast tumors: an initial experience.Acta radiologica open · 2022Article
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Authors and funding
8 authors.
Funding
Abstract
objectivesThe aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience. MATERIALS AND
methodsThis prospective study included 124 women (age range, 18-82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided biopsy between October 2015 and September 2016. Each lesion was examined with B-mode, elastography (Virtual Touch IQ [VTIQ]), Doppler, and CEUS, and different quantitative parameters were recorded for each modality. Four readers (2 experienced breast radiologists and 2 in-training) independently evaluated B-mode images of each lesion and assigned a BI-RADS (Breast Imaging Reporting and Data System) score. Using the area under the receiver operating characteristic curve (AUC), the most accurate quantitative parameter for each modality was chosen. These were then combined with the BI-RADS scores of all readers. Descriptive statistics and AUC were used to evaluate the diagnostic performance of mpUS.
resultsSixty-five lesions were malignant. MpUS with B-mode and 2 additional quantitative parameters (VTIQ and CEUS or Doppler) showed the highest diagnostic performance for all readers (averaged AUCs, 0.812-0.789 respectively vs 0.683 for B-mode, P = 0.0001). Both combinations significantly reduced the number of false-positive findings up to 46.9% (P < 0.0001).
conclusionsQuantitative mpUS with 2 different triple assessment modalities (B-mode, VTIQ elastography, CEUS, or Doppler) shows the best diagnostic performance for breast cancer diagnosis and leads to a significant reduction of false-positive biopsy recommendations, for both experienced and inexperienced readers.
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