Evidence map›Paper›PMID 30632749›Full record

ArticleThe Journal of organic chemistry2019

Catalytic One-Step Deoxytrifluoromethylation of Alcohols.

Francisco de Azambuja, Sydney M Lovrien, Patrick Ross, Brett R Ambler, Ryan A Altman

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Deoxytrifluoromethylation of Alcohols.Journal of the American Chemical Society · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francisco de AzambujaDepartment of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas 66045 , United States.ORCID 0000-0002-5537-5411
Sydney M LovrienDepartment of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas 66045 , United States.
Patrick RossDepartment of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas 66045 , United States.
Brett R AmblerDepartment of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas 66045 , United States.
Ryan A AltmanDepartment of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas 66045 , United States.ORCID 0000-0002-8724-1098

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
TRAINING GRANT IN DYNAMIC ASPECTS OF CHEMICAL BIOLOGYT32GM008545 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LAMB, AUDREY L · 1994 to 2019
$4.9M
Avance II 500 High Performance Digital NMR Spectrometer SystemS10RR024664 · NCRR · UNIVERSITY OF KANSAS LAWRENCE · PI VANDERVELDE, DAVID G · 2007 to 2007
$468k
AVIII HD 400 NMR spectrometer to replace existing DRX 400S10OD016360 · OD · UNIVERSITY OF KANSAS LAWRENCE · PI DOUGLAS, JUSTIN TRIGALET · 2014 to 2014
$297k
NCRR NIH HHS S10 RR024664NIGMS NIH HHS P20 GM103418NIGMS NIH HHS T32 GM008545NIH HHS S10 OD016360
6 · The paper itself

Abstract

A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access to target biologically active molecules, and should be useful for a variety of medicinal, agricultural, and materials chemists.

Indexed as

AlcoholsCatalysisCopperHydrocarbons, FluorinatedAlcoholsCopperHydrocarbons, Fluorinated

Identifiers

PMID30632749
PMCPMC6387626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.