ArticleJournal of veterinary internal medicine2019
Assessment of symmetric dimethylarginine as a biomarker of renal function in hyperthyroid cats treated with radioiodine.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.Journal of feline medicine and surgery · 2026Article
- Changes in serum symmetric dimethylarginine concentrations after treatment of feline hyperthyroidism with antithyroid medications.Journal of feline medicine and surgery · 2026Article
- High Prevalence of Lesions of Systemic Hypertension in Bile-Extracted Asiatic Black Bears (Animals : an open access journal from MDPI · 2025Article
- Comparison of serum creatinine, point-of-care symmetric dimethylarginine and renal imaging with glomerular filtration rate measured by renal scintigraphy in healthy and early chronic kidney diseased cats.Veterinary research communications · 2023Article
- Comparison of Three Different Diagnostic Assays for Fibroblast Growth Factor-23 (FGF-23) Measurements in Cats: A Pilot Study.Animals : an open access journal from MDPI · 2023Article
- Changes in symmetric dimethylarginine and glomerular filtration rates in hyperthyroid cats undergoing radioiodine therapy.Journal of feline medicine and surgery · 2023Article
- Hyperthyroid cats and their kidneys: a literature review.Australian veterinary journal · 2022Review
- Feline Comorbidities: Balancing hyperthyroidism and concurrent chronic kidney disease.Journal of feline medicine and surgery · 2022Review
- Renal biomarkers in cats: A review of the current status in chronic kidney disease.Journal of veterinary internal medicine · 2022Review
- Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism.Journal of veterinary internal medicine · 2021Article
- Plasma symmetric dimethylarginine and creatinine concentrations and glomerular filtration rate in cats with normal and decreased renal function.Journal of veterinary internal medicine · 2021Article
- Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine.Journal of veterinary internal medicine · 2020Article
- Symmetric dimethylarginine in hyperthyroid cats before and after treatment with radioactive iodine.Journal of feline medicine and surgery · 2020Article
- Assessment of symmetric dimethylarginine as a biomarker of renal function in hyperthyroid cats treated with radioiodine.Journal of veterinary internal medicine · 2019Article
- Efficacy of Urine Asymmetric Dimethylarginine Concentration to Predict Azotemia in Hyperthyroid Cats After Radio-Iodine Treatment.Journal of veterinary internal medicineArticle
- Association of Serum Symmetric Dimethylarginine Concentrations and Inflammation in Cats.Journal of veterinary internal medicineArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMeasurement of serum creatinine (sCr) and urea nitrogen fail to detect decreased renal function in many hyperthyroid cats because of low muscle mass and glomerular hyperfiltration of affected cats. Serum symmetric dimethylarginine (sSDMA) is an earlier and more sensitive renal biomarker than sCr.
objectiveEvaluate sSDMA as a biomarker of renal function in hyperthyroid cats before (T0) and 1 month after (T1) radioiodine ( ANIMALS: Forty-seven client-owned hyperthyroid nonazotemic cats were evaluated at T0 and T1.
methodsA prospective study in which sCr and sSDMA concentrations were determined in 47 hyperthyroid cats at T0 and at T1. Glomerular filtration rate (GFR) was estimated at T0 and T1 in 10 of these 47 cats using plasma exogenous creatinine clearance test.
resultsSerum SDMA was elevated (>14 μg/dL) in 6 of 47 cats at T0 and normalized after treatment in 4 of those cats. All cats remained nonazotemic after treatment. In 10 cats in which GFR was measured, correlation between GFR and sSDMA was low and not significant (τ CONCLUSIONS AND CLINICAL IMPORTANCE: Careful interpretation of mildly increased sSDMA with normal sCr in hyperthyroid cats is warranted as sSDMA values might normalize after resolution of hyperthyroidism in some cats. In this population of hyperthyroid cats, sSDMA was poorly correlated with GFR.
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