Evidence map›Paper›PMID 30632618›Full record

ArticleImmunology2019

Natural killer cell transcriptional control, subsets, receptors and effector function.

Daniel M Altmann

Open access · bronzeAbstract readEditorial
In one paragraph

Article in Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Immune related biomarkers for cancer metastasis to the brain.Experimental hematology & oncology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniel M AltmannDepartment of Medicine, Hammersmith Hospital, London, UK.
Hammersmith Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been considerable advances in characterization of the complexities of natural killer (NK) cell ligand recognition, activation, subsets and effector functions. The nature of the transcription factors that act to define distinctive functional programmes of NK cell subsets are now starting to be clarified as a consequence of studies in knockouts. Importantly, this is being extended to improved understanding of the nature of NK cell memory. As NK cell biology offers increasing resonance with analogous pathways in CD8 biology, some have made the case that immunology may sometimes benefit from a little less conceptual 'splitting' and a little more conceptual 'lumping.'

Indexed as

AnimalsCD8 AntigensHumansKiller Cells, NaturalMiceMice, KnockoutReceptors, ImmunologicSignal TransductionTranscription, GeneticCD8 AntigensReceptors, Immunologic

Identifiers

PMID30632618
PMCPMC6329198
OpenAlexW2910614820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.