Evidence map›Paper›PMID 30632385›Full record

ArticleBrain connectivity2019

Dynamic Functional Network Connectivity in Schizophrenia with Magnetoencephalography and Functional Magnetic Resonance Imaging: Do Different Timescales Tell a Different Story?

Lori Sanfratello, Jon M Houck, Vince D Calhoun

Abstract read
In one paragraph

Article in Brain connectivity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lori Sanfratello1 The Mind Research Network, Albuquerque, New Mexico.
Jon M Houck1 The Mind Research Network, Albuquerque, New Mexico.
Vince D Calhoun1 The Mind Research Network, Albuquerque, New Mexico.

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI SUI, JING · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
NEURAL MECHANISMS OF SCHIZOPHRENIAP20RR021938 · NCRR · THE MIND RESEARCH NETWORK · PI JUNG, REX · 2008 to 2011
$9.4M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Imaging Brain Activity in Substance Use TreatmentK01AA021431 · NIAAA · UNIVERSITY OF NEW MEXICO · PI HOUCK, JON M. · 2013 to 2017
$837k
NCRR NIH HHS P20 RR021938NIAAA NIH HHS K01 AA021431NIAAA NIH HHS L30 AA026181NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIGMS NIH HHS P20 GM103472NIMH NIH HHS R01 MH118695
6 · The paper itself

Abstract

The importance of how brain networks function together to create brain states has become increasingly recognized. Therefore, an investigation of eyes-open resting-state dynamic functional network connectivity (dFNC) of healthy controls (HC) versus that of schizophrenia patients (SP) via both functional magnetic resonance imaging (fMRI) and a novel magnetoencephalography (MEG) pipeline was completed. The fMRI analysis used a spatial independent component analysis (ICA) to determine the networks on which the dFNC was based. The MEG analysis utilized a source space activity estimate (minimum norm estimate [MNE]/dynamic statistical parametric mapping [dSPM]) whose result was the input to a spatial ICA, on which the networks of the MEG dFNC were based. We found that dFNC measures reveal significant differences between HC and SP, which depended on the imaging modality. Consistent with previous findings, a dFNC analysis predicated on fMRI data revealed HC and SP remain in different overall brain states (defined by a k-means clustering of network correlations) for significantly different periods of time, with SP spending less time in a highly connected state. The MEG dFNC, in contrast, revealed group differences in more global statistics: SP changed between meta-states (k-means cluster states that are allowed to overlap in time) significantly more often and to states that were more different, relative to HC. MEG dFNC also revealed a highly connected state where a significant difference was observed in interindividual variability, with greater variability among SP. Overall, our results show that fMRI and MEG reveal between-group functional connectivity differences in distinct ways, highlighting the utility of using each of the modalities individually, or potentially a combination of modalities, to better inform our understanding of disorders such as schizophrenia.

Indexed as

AdultBrainBrain MappingCluster AnalysisConnectomeFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMaleMiddle AgedNerve NetRestSchizophreniadynamic functional network connectivity (dFNC)functional magnetic resonance imaging (fMRI)magnetoencephalography (MEG)schizophrenia

Identifiers

PMID30632385
PMCPMC6479258

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.