ArticleActa physiologica (Oxford, England)2019
An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery.
Article in Acta physiologica (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Myonuclear permanence in skeletal muscle memory: a systematic review and meta-analysis of human and animal studies.Journal of cachexia, sarcopenia and muscle · 2022Pooled it
- Obesity is a risk factor for developing critical condition in COVID-19 patients: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial HExperimental gerontology · 2022Trial
- Neuromuscular electrical stimulation and protein during bed rest increases CD11bApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2020Trial
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Multicellular senescence impairs skeletal muscle recovery following disuse in aging.Science advances · 2026Article
- Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle.The Journal of physiology · 2026Article
- HMGB1: a key molecule linking chronic inflammation to complications in type 2 diabetes mellitus and a target for exercise intervention.Frontiers in endocrinology · 2026Review
- Interplay Between Insulin Resistance and Immune Dysregulation in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions.ImmunoTargets and therapy · 2025Review
- Skeletal muscle memory: implications for sports, aging and nutrition.Frontiers in nutrition · 2025Review
- Inactivity-mediated molecular adaptations: Insights from a preclinical model of physical activity reduction.Physiological reports · 2024Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
- What Happened Pre- and during COVID-19 in South Korea? Comparing Physical Activity, Sleep Time, and Body Weight Status.International journal of environmental research and public health · 2021Article
- Obesity pandemic during COVID-19 outbreak: Narrative review and future considerations.Clinical nutrition (Edinburgh, Scotland) · 2021Review
- Mutant strains of SARS-CoV-2 are more prone to infect obese patient: a review.Wiener klinische Wochenschrift · 2021Review
- Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients.Biology · 2020Review
- Fat mass affects nutritional status of ICU COVID-19 patients.Journal of translational medicine · 2020Observational
- The Stanford Hall consensus statement for post-COVID-19 rehabilitation.British journal of sports medicine · 2020Article
- Proper Management of People with Obesity during the COVID-19 Pandemic.Journal of obesity & metabolic syndrome · 2020Article
- Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance.Obesity (Silver Spring, Md.) · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundMechanisms underlying physical inactivity-induced insulin resistance are not well understood. In addition to a role in muscle repair, immune cell populations such as macrophages may regulate insulin sensitivity.
aimThe aim of this study was to examine if the dynamic changes in insulin sensitivity during and after recovery from reduced physical activity corresponded to changes in skeletal muscle macrophages.
methodsIn this prospective clinical study, we collected muscle biopsies from healthy older adults (70 ± 2 years, n = 12) before and during a hyperinsulinaemic-euglycaemic clamp and this occurred before (PRE) and after 2-week reduced physical activity (RA), and following 2-week of recovery (REC). Insulin sensitivity (hyperinsulinaemic-euglycaemic clamp), skeletal muscle mRNA expression of inflammatory markers, and immunofluorescent quantification of skeletal muscle macrophages, myofibre-specific satellite cell and capillary content were assessed.
resultsInsulin sensitivity was decreased following reduced activity and rebounded following recovery above PRE levels. We observed an increase (P < 0.01) in muscle macrophages (CD68
conclusionThese findings suggested that a dynamic response of skeletal muscle macrophages following acute changes in physical activity in healthy older adults is related to insulin sensitivity.
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