Evidence map›Paper›PMID 30632269›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2019

Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem-Like Cells.

Weiqiang Chen, Steven G Allen, Weiyi Qian, Zifeng Peng, Shuo Han, Xiang Li, Yubing Sun, Chelsea Fournier, Liwei Bao, Raymond H W Lam and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. The cellular mechanobiology of aging: from biology to mechanics.Annals of the New York Academy of Sciences · 2021
    Review
  6. Article
  7. Article
  8. Cancer Stem Cell Plasticity - A Deadly Deal.Frontiers in molecular biosciences · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Weiqiang ChenDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.ORCID 0000-0002-9469-8328
Steven G AllenProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Weiyi QianDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.
Zifeng PengDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Shuo HanDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiang LiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Yubing SunMechanical and Industrial Engineering, University of Massachusetts, Amherst, MA, 01003, USA.
Chelsea FournierUndergraduate Program in Neuroscience, University of Michigan, Ann Arbor, MI, 48109, USA.
Liwei BaoDepartment of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Raymond H W LamDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Sofia D MerajverProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Jianping FuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-9629-6739
University of Michigan · USCity University of Hong Kong · HKNew York University · USState University of New York · USUniversity of Massachusetts Amherst · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
VACCINIA PSA FOR ANDROGEN-MODULATED POST-SURGICAL RECURRENCE OF PROSTATE CANCERP50CA069568 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COONEY, KATHLEEN A · 1995 to 2013
$31.3M
Engineered Glioblastoma Tumor Immunity for Personalized ImmunotherapyR21EB025406 · NIBIB · NEW YORK UNIVERSITY · PI CHEN, WEIQIANG, SNUDERL, MATIJA · 2018 to 2020
$610k
Interleukin-4 Drives Tumor-Associated Macrophage Polarization to Promote Tumor GrF30CA173910 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, STEVEN · 2013 to 2016
$129k
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NCI NIH HHS F30 CA173910NCI NIH HHS P50 CA069568NIBIB NIH HHS R21 EB025406
6 · The paper itself

Abstract

Cancer stem-like cells (CSCs) have been shown to initiate tumorigenesis and cancer metastasis in many cancer types. Although identification of CSCs through specific marker expression helps define the CSC compartment, it does not directly provide information on how or why this cancer cell subpopulation is more metastatic or tumorigenic. In this study, the functional and biophysical characteristics of aggressive and lethal inflammatory breast cancer (IBC) CSCs at the single-cell level are comprehensively profiled using multiple microengineered tools. Distinct functional (cell migration, growth, adhesion, invasion and self-renewal) and biophysical (cell deformability, adhesion strength and contractility) properties of ALDH+ SUM149 IBC CSCs are found as compared to their ALDH- non-CSC counterpart, providing biophysical insights into why CSCs has an enhanced propensity to metastasize. It is further shown that the cellular biophysical phenotype can predict and determine IBC cells' tumorigenic ability. SUM149 and SUM159 IBC cells selected and modulated through biophysical attributes-adhesion and stiffness-show characteristics of CSCs in vitro and enhance tumorigenicity in in vivo murine models of primary tumor growth. Overall, the multiparametric cellular biophysical phenotyping and modulation of IBC CSCs yields a new understanding of IBC's metastatic properties and how they might develop and be targeted for therapeutic interventions.

Indexed as

BiophysicsAldehyde DehydrogenaseBiomechanical PhenomenaCarcinogenesisCell AdhesionCell Line, TumorFemaleHumansInflammatory Breast NeoplasmsNeoplastic Stem CellsPhenotypeAldehyde Dehydrogenasebiophysical propertycancer stem cellsinflammatory breast cancer

Identifiers

PMID30632269
PMCPMC6486377
OpenAlexW2908871841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.