ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Using health-related quality of life to predict cardiovascular disease events.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- The effect of telehealth-based medical nutrition therapy on cardiovascular disease risk factors in a rural population: a secondary analysis of outcomes related to nutrition, health and well-being from the healthy rural hearts randomised controlled trial.The international journal of behavioral nutrition and physical activity · 2025Trial
- Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials.Cardiovascular drugs and therapy · 2024Trial
- Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026Review
- Preoperative quality of life in patients undergoing liver surgery.Surgery open science · 2026Article
- Predictors of quality of life after cardiac procedures: a mixed-methods study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Assessing Quality of Life in Genetic Cardiomyopathies: A Scoping Review.International journal of environmental research and public health · 2026Article
- Measuring Patient-Reported Outcomes in Ischemic Heart Disease: Validation of the Greek HeartQoL Questionnaire.American journal of medicine open · 2025Article
- Age, Sex, and Central Adiposity as Determinants of Autonomic Nervous System Reactivity in Adults.Medicina (Kaunas, Lithuania) · 2025Article
- Loneliness and health-related quality of life in Chinese adolescents: the mediating role of depressive symptoms and the moderating role of age.Social psychiatry and psychiatric epidemiology · 2025Article
- Cardiovascular Disease Multimorbidity and Decreased Health-Related Quality of Life in Haiti: A Cross-Sectional Study.Journal of the American Heart Association · 2025Observational
- Impact of visual presentation of atherosclerotic carotid plaque on cardiovascular risk profile using mHealth technologies.NPJ digital medicine · 2025Article
- Embracing the promise of patient reported outcome measures in cardiology.European heart journal. Quality of care & clinical outcomes · 2024Article
- No Obesity Paradox for Health-Related Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Insights from the VIDA Multicenter Study.Journal of clinical medicine · 2024Article
- Development and validation of electronic health record-based, machine learning algorithms to predict quality of life among family practice patients.Scientific reports · 2024Article
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- Objectively Measured Physical Activity and Sedentary Behaviour on Cardiovascular Risk and Health-Related Quality of Life in Adults: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
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- Association between healthy lifestyle factors and health-related quality of life among Chinese adolescents: the moderating role of gender.Health and quality of life outcomes · 2023Article
- Positivity and Health Locus of Control: Key Variables to Intervene on Well-Being of Cardiovascular Disease Patients.Journal of personalized medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeAlthough strong associations between self-reported health and mortality exist, quality of life is not conceptualized as a cardiovascular disease (CVD) risk factor. Our objective was to assess the independent association between health-related quality of life (HRQOL) and incident CVD.
methodsThis study used the REasons for Geographic And Racial Differences in Stroke data, which enrolled 30,239 adults from 2003 to 2007 and followed them over 10 years. We included 22,229 adults with no CVD history at baseline. HRQOL was measured using the SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores, which range from 0 to 100, with higher scores indicating better HRQOL. Scores were normed to the general US population with mean 50 and standard deviation 10. We constructed a four-level HRQOL variable: (1) individuals with PCS & MCS < 50, (2) PCS < 50 & MCS ≥ 50, (3) MCS < 50 & PCS ≥ 50, and (4) PCS & MCS ≥ 50, which was the reference. The primary outcome was incident CVD (non-fatal myocardial infarction (MI), fatal MI or coronary heart disease (CHD) death, fatal and non-fatal stroke). Cox proportional hazards models examined associations between HRQOL and CVD.
resultsMedian follow-up was 8.4 (IQR 5.9-10.0) years. We observed 1766 CVD events. Compared to having PCS & MCS ≥ 50, having MCS & PCS < 50 was associated with increased CVD risk (aHR 1.46; 95% 1.24-1.70), adjusting for demographics, comorbidities, and CVD risk factors. Associations between MCS & PCS < 50 and CVD were consistent for CHD (aHR 1.54 [1.26-1.89]) and stroke (aHR 1.35 [1.05-1.72]) endpoints.
conclusionsGiven strong, adjusted associations between poor HRQOL and incident CVD, self-reported health may be an excellent complement to current approaches to CVD risk identification.
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