ArticleLab on a chip2019
Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.
Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Demonstration of topological acoustic tweezing for robust mass transport.Science advances · 2026Article
- Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Airborne Acoustic Vortex End Effector-based Contactless, Multi-mode, Programmable Control of Object Surfing.Advanced materials technologies · 2024Article
- Acoustofluidic Actuation of Living Cells.Micromachines · 2024Review
- An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood.Microsystems & nanoengineering · 2024Article
- A review of acoustofluidic separation of bioparticles.Biophysical reviews · 2023Review
- Biomolecular actuators for genetically selective acoustic manipulation of cells.Science advances · 2023Article
- From the teapot effect to tap-triggered self-wetting: a 3D self-driving sieve for whole blood filtration.Microsystems & nanoengineering · 2023Article
- Potential of the acoustic micromanipulation technologies for biomedical research.Biomicrofluidics · 2021Article
- Acoustofluidic Droplet Sorter Based on Single Phase Focused Transducers.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- Flexural wave-based soft attractor walls for trapping microparticles and cells.Lab on a chip · 2021Article
- Acoustofluidic multi-well plates for enrichment of micro/nano particles and cells.Lab on a chip · 2020Article
- Scaling of deterministic lateral displacement devices to a single column of bumping obstacles.Lab on a chip · 2020Article
- Influence of Hydrodynamics and Hematocrit on Ultrasound-Induced Blood Plasmapheresis.Micromachines · 2020Article
- Acoustic Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Platelet separation is a crucial step for both blood donation and treatment of essential thrombocytosis. Here we present an acoustofluidic device that is capable of performing high-throughput, biocompatible platelet separation using sound waves. The device is entirely made of plastic material, which renders the device disposable and more suitable for clinical use. We used this device to process undiluted human whole blood, and we demonstrate a sample throughput of 20 mL min-1, a platelet recovery rate of 87.3%, and a red/white blood cell removal rate of 88.9%. We preserved better platelet function and integrity for isolated platelets than those which are isolated using established methods. Our device features advantages such as rapid fabrication, high throughput, and biocompatibility, so it is a promising alternative to existing platelet separation approaches.
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Registered trials
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