Evidence map›Paper›PMID 30631799›Full record

ArticleACS biomaterials science & engineering2018

Biodegradable Simvastatin-Containing Polymeric Prodrugs with Improved Drug Release.

A D Thilanga Liyanage, Alexander J Chen, David A Puleo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

A D Thilanga LiyanageF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, 522 Robotics and Manufacturing Building, 143 Graham Avenue, University of Kentucky, Lexington, KY, USA.
Alexander J ChenF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, 522 Robotics and Manufacturing Building, 143 Graham Avenue, University of Kentucky, Lexington, KY, USA.
David A PuleoF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, 522 Robotics and Manufacturing Building, 143 Graham Avenue, University of Kentucky, Lexington, KY, USA.
University of Kentucky · US

Funding

Biodegradable Polymerized SimvastatinR21EB017902 · NIBIB · UNIVERSITY OF KENTUCKY · PI PULEO, DAVID A. · 2014 to 2015
$411k
NIBIB NIH HHS R21 EB017902
6 · The paper itself

Abstract

Simvastatin was previously converted to a polymeric prodrug with higher drug loading, but the hydrophobic nature of the poly(simvastatin) component of the block copolymer led to slow release of the drug

Indexed as

controlled releasedegradable polymerglycolidePolymeric prodrugsimvastatin

Identifiers

PMID30631799
PMCPMC6322697
OpenAlexW2898690351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.