Evidence map›Paper›PMID 30631481›Full record

ArticleNPJ science of learning2018

A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children.

Miao Li, Jeffrey G Malins, Mellissa M C DeMille, Maureen W Lovett, Dongnhu T Truong, Katherine Epstein, Cheryl Lacadie, Chintan Mehta, Joan Bosson-Heenan, Jeffrey R Gruen and 2 more

Abstract read
In one paragraph

Article in NPJ science of learning, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Effect of READ1 on latent profiles of reading disorder and comorbid attention and language impairment subtypes.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miao Li *1Department of Curriculum and Instruction, College of Education, University of Houston, Houston, TX USA.ORCID 0000-0002-6756-8122
Jeffrey G Malins *3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.ORCID 0000-0002-2932-256X
Mellissa M C DeMille3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.
Maureen W Lovett5Neurosciences and Mental Health Program, Learning Disabilities Research Program, The Hospital for Sick Children, University of Toronto, Toronto, ON Canada.
Dongnhu T Truong3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.
Katherine Epstein3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.
Cheryl Lacadie6Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USA.
Chintan Mehta3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.
Joan Bosson-Heenan3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.
Jeffrey R Gruen3Department of Pediatrics, Yale University School of Medicine, New Haven, CT USA.ORCID 0000-0001-7640-2071
Jan C Frijters8Faculty of Social Sciences, Department of Child and Youth Studies, Brock University, St. Catharines, ON Canada.
GRaD Study Consortium

Funding

VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9M
Discovery of the 6p21.3 Reading Disability GeneR01NS043530 · NINDS · YALE UNIVERSITY · PI GRUEN, JEFFREY R · 2003 to 2010
$4.3M
NICHD NIH HHS P50 HD027802NINDS NIH HHS R01 NS043530
6 · The paper itself

Abstract

Children with poor reading comprehension despite typical word reading skills were examined using neuropsychological, genetic, and neuroimaging data collected from the Genes, Reading and Dyslexia Study of 1432 Hispanic American and African American children. This unexpected poor comprehension was associated with profound deficits in vocabulary, when compared to children with comprehension skills consistent with their word reading. Those with specific comprehension difficulties were also more likely to have RU2Short alleles of READ1 regulatory variants of

Identifiers

PMID30631481
PMCPMC6249284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.