Evidence map›Paper›PMID 30631414›Full record

ReviewJournal of osteoporosis2018

The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms.

Ahmad M Al-Bashaireh, Linda G Haddad, Michael Weaver, Xing Chengguo, Debra Lynch Kelly, Saunjoo Yoon

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of osteoporosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 7 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 7 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. A meta-analysis of smoking and fracture risk to update the FRAX® tool.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  2. Risk factors for refracture or new vertebral compression fractures after percutaneous vertebroplasty: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  3. Pooled it
  4. Gender differences between smoking and the risk of hip fracture.Journal of bone and mineral metabolism · 2024
    Pooled it
  5. Pooled it
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  7. The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Pooled it
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  11. Impact of current and previous smoking on fracture risk in older women: the role of physical function, bone density, and bone microarchitecture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ahmad M Al-BashairehPh.D., College of Nursing, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-1050-1680
Linda G HaddadProfessor, Associate Director for Graduate Program, College of Health and Human Services, University of North Carolina Wilmington, Wilmington, NC, USA.ORCID 0000-0001-6691-3599
Michael WeaverProfessor, Associate Dean for Research and Scholarship, College of Nursing, University of Florida, Gainesville, FL, USA.
Xing ChengguoProfessor, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Debra Lynch KellyAssistant Professor, College of Nursing, University of Florida, Gainesville, FL, USA.
Saunjoo YoonAssociate Professor, College of Nursing, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-5669-8709
University of Florida · USUniversity of North Carolina Wilmington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence demonstrates that tobacco smoking causes an imbalance in bone turnover, leading to lower bone mass and making bone vulnerable to osteoporosis and fracture. Tobacco smoke influences bone mass indirectly through alteration of body weight, parathyroid hormone-vitamin D axis, adrenal hormones, sex hormones, and increased oxidative stress on bony tissues. Also, tobacco smoke influences bone mass through a direct effect on osteogenesis and angiogenesis of bone. A RANKL-RANK-OPG pathway is an essential regulatory pathway for bone metabolism and its importance lies in its interaction with most of the pathophysiologic mechanisms by which smoking influences bone mass. Both first- and secondhand smoke adversely affect bone mass; smoking cessation seems to reverse the effect of smoking and improve bone health. Recent advances in research on bone turnover markers could advance scientific knowledge regarding the mechanisms by which smoking may influence bone mass.

Identifiers

PMID30631414
PMCPMC6304634
OpenAlexW2903346619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.