ArticleInternational journal of pediatrics2018
Sex-Specific Association between Childhood BMI Trajectories and Asthma Phenotypes.
Article in International journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The association between body mass index and asthma in children: a cross‑sectional study from NHANES 1999 to 2020.Scientific reports · 2025Article
- The importance of missing data in estimating BMI trajectories.Scientific reports · 2024Article
- Long-term characterization of cognitive phenotypes in children with seizures over 36 months.Epilepsy & behavior : E&B · 2024Article
- Identification of Sex-Specific Genetic Polymorphisms Associated with Asthma in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data.Journal of asthma and allergy · 2023Article
- BMI trajectories, morbidity, and mortality in England: a two-step approach to estimating consequences of changes in BMI.Obesity (Silver Spring, Md.) · 2022Article
- Obesity-associated asthma in childhood.Allergologie select · 2020Article
- Novel Insights on Sex-Related Differences in Asthma.Current allergy and asthma reports · 2019Review
- Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma and obesity are two common health problems in the pediatric population. Obesity is associated with several comorbidities which are of great consequence. Excess adipose tissue has been linked to asthma in a number of studies. However, little is known about childhood body mass index (BMI) trajectories and the development of asthma phenotypes.
objectiveThe current study aims to investigate the significance of BMI trajectories over childhood and the risk of asthma phenotypes.
methodsThe current study is a prospective cohort of children aged 0-2 years who were followed every two years for eight years through cycles one to five in the National Longitudinal Survey of Children and Youths (NLSCY). Statistical analysis: a latent class growth modelling (LCGM) method was used to identify BMI trajectory patterns from cycles one to five. Multiple imputation (number of imputations=5) was carried out to impute children with missing values on height or weight information. Sampling weights and 1,000 bootstrap weights were used in SAS
resultsThe study consisted of 571,790 males and 549,230 females. Among them, 46% of children showed an increasing trajectory in terms of change in BMI percentile during childhood, followed by the stable-trajectory group (41%) and decreasing-trajectory group (13%). After controlling for confounding factors, females in the increasing BMI trajectory group were four times more likely to be associated with persistent asthma (OR = 4.09; 95% CI:1.04-16.15; p = 0.0442) than females in the stable BMI trajectory group. No such relationship was found in males. The BMI trajectory was not significantly associated with risk of transient asthma for either sex.
conclusionWe report a female-specific association between increasing adiposity, measured by BMI, and persistent asthma.
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Registered trials
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