ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
Association between early-stage chronic kidney disease and reduced choroidal thickness in essential hypertensive patients.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Exudative retinal detachment and hypertensive choroidopathy in a patient with suspected HELLP syndrome: a case report.BMC ophthalmology · 2025Article
- Early Renal Dysfunction and Reduced Retinal Vascular Density Assessed by Angio-OCT in Hypertensive Patients.Biomedicines · 2025Article
- Relationship Between Renal Resistive Index and Retinal Vascular Density in Individuals with Hypertension.Biomedicines · 2025Article
- Relationship Between Short-Term Blood Pressure Variability and Choroidal-Retinal Thicknesses Assessed by Optical Coherence Tomography in Hypertensive Subjects.Journal of personalized medicine · 2024Article
- Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients.Life (Basel, Switzerland) · 2024Article
- Choroidal Vascularity Index and Choroidal Structural Changes in Children With Nephrotic Syndrome.Translational vision science & technology · 2024Article
- Evaluation of an Automated Choroid Segmentation Algorithm in a Longitudinal Kidney Donor and Recipient Cohort.Translational vision science & technology · 2023Article
- Deep learning in optical coherence tomography: Where are the gaps?Clinical & experimental ophthalmology · 2023Review
- Evaluation of subclinical changes in recently diagnosed pediatric hypertension patients without hypertensive retinopathy: an OCT study.International ophthalmology · 2023Article
- Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes.medRxiv : the preprint server for health sciences · 2023Article
- The Association Between Lipid Profile and Subfoveal Choroidal Thickness in Chinese Patients with Proliferative Diabetic Retinopathy Secondary to Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies.Nutrients · 2022Review
- Hypertensive eye disease.Nature reviews. Disease primers · 2022Review
- Artificial Intelligence in Predicting Systemic Parameters and Diseases From Ophthalmic Imaging.Frontiers in digital health · 2022Review
- Article
- Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Correlations between choroidal thickness and renal function in patients with retinal vein occlusion.Scientific reports · 2020Article
- Effects of Systemic Profiles on Choroidal Thickness in Treatment-Naïve Eyes With Diabetic Retinopathy.Investigative ophthalmology & visual science · 2020Observational
- The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons.Kidney international · 2020Review
- Choroidal Thickness in Diabetes and Diabetic Retinopathy: A Swept Source OCT Study.Investigative ophthalmology & visual science · 2020Article
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10 authors.
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Abstract
The introduction in the past few years of advanced optical coherence tomography (OCT) techniques has greatly increased our understanding of the choroid, which is the most important vascular layer of the eye. Our study aimed to assess choroidal thickness by using swept-source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without early-stage chronic kidney disease (CKD). We enrolled 100 EHs, of whom 65 were without kidney damage, and 35 had stage 1-3 CKD. In all of the participants, SS-OCT and a routine biochemical workup were performed. Glomerular filtration rate (GFR) was estimated by the CKD Epidemiology Collaboration equation (eGFR). CKD was defined in agreement with the Kidney Disease Outcomes Quality Initiative Kidney Disease: Improving Global Outcomes 2002 guidelines. OCT measurements were performed according to the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol, which divides the macula into nine subfields. The circular grid consists of three concentric rings. EHs with CKD showed thinner choroidal thicknesses than those without it (all p < 0.05), even after adjustment for potential confounding factors. Overall choroidal thickness correlated significantly and directly with eGFR (r = 0.36) and negatively with urinary albumin excretion (r = -0.39). The association of choroidal thickness with CKD was confirmed in multiple logistic regression analyses once the effects of age and other confounding variables were accounted for. The odds ratio of having early-stage CKD associated with a standard deviation increase in overall choroidal thickness was 0.43 (0.24-0.75, 95% confidence interval; p = 0.007). In conclusion, our study confirms the close relationships between changes in ocular microcirculation and renal dysfunction.
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