Evidence map›Paper›PMID 30631106›Full record

ArticleScientific reports2019

Induced cross-resistance of BRAF

Sarah Erdmann, Diana Seidel, Heinz-Georg Jahnke, Marie Eichler, Jan-Christoph Simon, Andrea A Robitzki

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Costunolide suppresses melanoma growth via the AKT/mTOR pathwayAmerican journal of cancer research · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Inhibitors of HSP90 in melanoma.Apoptosis : an international journal on programmed cell death · 2020
    Review
  14. Cancer stem cells, plasticity, and drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2020
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah ErdmannCentre for Biotechnology and Biomedicine (BBZ), Universität Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103, Leipzig, Germany.
Diana SeidelCentre for Biotechnology and Biomedicine (BBZ), Universität Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103, Leipzig, Germany.
Heinz-Georg JahnkeCentre for Biotechnology and Biomedicine (BBZ), Universität Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103, Leipzig, Germany.
Marie EichlerCentre for Biotechnology and Biomedicine (BBZ), Universität Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103, Leipzig, Germany.
Jan-Christoph SimonLeipzig University Medical Centre, Department of Dermatology, Venerology and Allergology, Philipp-Rosenthal-Str. 23, 04103, Leipzig, Germany.
Andrea A RobitzkiCentre for Biotechnology and Biomedicine (BBZ), Universität Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103, Leipzig, Germany. andrea.robitzki@bbz.uni-leipzig.de.
Leipzig University · DE

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 5485142Sächsische Aufbaubank (Development Bank of Saxony) 100261990
6 · The paper itself

Abstract

The maximum response and 10-year survival rate for metastatic melanoma patients treated with standardised chemotherapy is still less than 15% and 10%, respectively. In contrast, oncogene targeting was found a promising tool for killing of BRAF

Indexed as

Drug Resistance, NeoplasmMutation, MissenseAntineoplastic AgentsCell Line, TumorDacarbazineHumansMelanocytesProto-Oncogene Proteins B-rafVemurafenibAntineoplastic AgentsBRAF protein, humanDacarbazineProto-Oncogene Proteins B-rafVemurafenib

Identifiers

PMID30631106
PMCPMC6328535
OpenAlexW2921712342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.