ArticleScientific reports2019
Potential role of host-derived quorum quenching in modulating bacterial colonization in the moon jellyfish Aurelia aurita.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Multi-omics reveals the inhibition of asexual reproduction in the jellyfish Aurelia coerulea polyp by Bacillus pacificus.Environmental microbiome · 2025Article
- A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.Communications biology · 2025Review
- Metagenomic insights into jellyfish-associated microbiome dynamics during strobilation.ISME communications · 2024Article
- The Life Cycle ofMicrobiology spectrum · 2023Article
- First insights into theFrontiers in microbiology · 2023Article
- Dishonest Signaling in Microbial Conflicts.Frontiers in microbiology · 2022Article
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- Article
- Cultivable microbiota associated with Aurelia aurita and Mnemiopsis leidyi.MicrobiologyOpen · 2020Article
- Quorum Sensing Inhibition by Marine Bacteria.Marine drugs · 2019Review
- Neutrality in the Metaorganism.PLoS biology · 2019Article
- Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host Interactomes.Frontiers in microbiology · 2019Article
- Boron-containing compounds in Dentistry: a narrative review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicellular organisms can be regarded as metaorganisms, comprising of a macroscopic host interacting with associated microorganisms. Within this alliance, the host has to ensure attracting beneficial bacteria and defending against pathogens to establish and maintain a healthy homeostasis. Here, we obtained several lines of evidence arguing that Aurelia aurita uses interference with bacterial quorum sensing (QS) - quorum quenching (QQ) - as one host defense mechanism. Three A. aurita-derived proteins interfering with bacterial QS were identified by functionally screening a metagenomic library constructed from medusa-derived mucus. Native expression patterns of these host open reading frames (ORFs) differed in the diverse life stages (associated with different microbiota) pointing to a specific role in establishing the developmental stage-specific microbiota. Highly increased expression of all QQ-ORFs in germ-free animals further indicates their impact on the microbiota. Moreover, incubation of native animals with pathogenic bacteria induced expression of the identified QQ-ORFs arguing for a host defense strategy against confronting bacteria by interference with bacterial QS. In agreement, immobilized recombinant QQ proteins induced restructuring of polyp-associated microbiota through changing abundance and operational taxonomic unit composition. Thus, we hypothesize that additional to the immune system host-derived QQ-activities potentially control bacterial colonization.
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