Evidence map›Paper›PMID 30631074›Full record

ArticleNature communications2019

Shifts in the selectivity filter dynamics cause modal gating in K

Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 75 citations in OpenAlex.

  1. Molecular action of NZ2114, a superior plectasin derivative.npj antimicrobials and resistance · 2026
    Article
  2. Article
  3. OPTO: Automated Optimization for Solid-State NMR Spectroscopy.Journal of the American Chemical Society · 2025
    Article
  4. Article
  5. Article
  6. Water inside the Selectivity Filter of a KJournal of the American Chemical Society · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  11. Article
  12. Intrinsically disordered ectodomain modulates ion permeation through a metal transporter.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Chemical reviews · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Shehrazade JekhmaneNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.
João Medeiros-SilvaNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3532-4390
Jing LiDepartment of Biochemistry and Molecular Biology, The University of Chicago, 929 E57th Street, Chicago, IL, 60637, USA.ORCID http://orcid.org/0000-0003-3277-6818
Felix KümmererNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4697-4658
Christoph Müller-HermesNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.
Marc BaldusNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-7068-5613
Benoît RouxDepartment of Biochemistry and Molecular Biology, The University of Chicago, 929 E57th Street, Chicago, IL, 60637, USA.
Markus WeingarthNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands. m.h.weingarth@uu.nl.ORCID http://orcid.org/0000-0003-0831-8673
Utrecht University · NLUniversity of Chicago · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2010 to 2017
$31.9M
Computational Studies of Ion Channels - Resubmission 01R01GM062342 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI ROUX, BENOIT · 2001 to 2022
$8.7M
NIGMS NIH HHS R01 GM062342NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

Spontaneous activity shifts at constant experimental conditions represent a widespread regulatory mechanism in ion channels. The molecular origins of these modal gating shifts are poorly understood. In the K

Indexed as

Amino Acid SequenceBacterial ProteinsHydrogen BondingIon Channel GatingMolecular Dynamics SimulationMutationPotassiumPotassium ChannelsProtein ConformationSequence Homology, Amino AcidBacterial ProteinsPotassiumPotassium Channels

Identifiers

PMID30631074
PMCPMC6328603
OpenAlexW2909605143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.