ArticleNature communications2019
Ultrafast data mining of molecular assemblies in multiplexed high-density super-resolution images.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin.Nature communications · 2025Article
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- Decreasing microtubule detyrosination modulates Nav1.5 subcellular distribution and restores sodium current in mdx cardiomyocytes.Cardiovascular research · 2024Article
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- Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions.Science advances · 2022Article
- The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells.Nature communications · 2022Article
- Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- USP1-trapping lesions as a source of DNA replication stress and genomic instability.Nature communications · 2022Article
- A basal-level activity of ATR links replication fork surveillance and stress response.Molecular cell · 2021Article
- Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.Nature communications · 2021Article
- Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains.Circulation. Arrhythmia and electrophysiology · 2020Article
- Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters.Molecular cell · 2020Article
- Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.PLoS genetics · 2020Article
- Quantification of trans-synaptic protein alignment: A data analysis case for single-molecule localization microscopy.Methods (San Diego, Calif.) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Multicolor single-molecule localization super-resolution microscopy has enabled visualization of ultrafine spatial organizations of molecular assemblies within cells. Despite many efforts, current approaches for distinguishing and quantifying such organizations remain limited, especially when these are contained within densely distributed super-resolution data. In theory, higher-order correlation such as the Triple-Correlation function is capable of obtaining the spatial configuration of individual molecular assemblies masked within seemingly discorded dense distributions. However, due to their enormous computational cost such analyses are impractical, even for high-end computers. Here, we developed a fast algorithm for Triple-Correlation analyses of high-content multiplexed super-resolution data. This algorithm computes the probability density of all geometric configurations formed by every triple-wise single-molecule localization from three different channels, circumventing impractical 4D Fourier Transforms of the entire megapixel image. This algorithm achieves 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.