ArticleNature communications2019
A disinhibitory mechanism biases Drosophila innate light preference.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Inhibitory circuits control leg movements duringeLife · 2026Article
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- SIFamide-dependent synaptic plasticity in male-specific GABAergic neurons underlies experience-modulated mating behaviors.iScience · 2025Article
- Neuropeptide-mediated synaptic plasticity regulates context-dependent mating behaviors in Drosophila.PLoS biology · 2025Article
- Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior ineLife · 2024Article
- Selection and validation of reliable reference genes for quantitative real-time PCR in Barnyard millet (Echinochloa spp.) under varied abiotic stress conditions.Scientific reports · 2023Article
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
- Circuit analysis reveals a neural pathway for light avoidance in Drosophila larvae.Nature communications · 2022Article
- Drosophila Larval Light-Avoidance is Negatively Regulated by Temperature Through Two Pairs of Central Brain Neurons.Neuroscience bulletin · 2022Article
- Genetic Transsynaptic Techniques for Mapping Neural Circuits inFrontiers in neural circuits · 2021Review
- Useful road maps: studying Drosophila larva's central nervous system with the help of connectomics.Current opinion in neurobiology · 2020Review
- CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is largely unclear. Here we show that Drosophila larval light preference behavior is regulated by a disinhibitory mechanism. In the disinhibitory circuit, a pair of GABAergic neurons exerts tonic inhibition on one pair of contralateral projecting neurons that control larval reorientation behavior. When a larva enters the light area, the reorientation-controlling neurons are disinhibited to allow reorientation to occur as the upstream inhibitory neurons are repressed by light. When the larva exits the light area, the inhibition on the downstream neurons is restored to repress further reorientation and thus prevents the larva from re-entering the light area. We suggest that disinhibition may serve as a common neural mechanism for animal innate preference behavior.
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