Trial reportNature communications2019
Indirect protection from vaccinating children against influenza in households.
Trial report in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Influenza antibody breadth and effector functions are immune correlates from acquisition of pandemic infection of children.Nature communications · 2024Trial
- Trial
- Role-specific household contact patterns in urban and rural China: Implications for influenza household transmission.Infectious Disease Modelling · 2027Article
- Influenza vaccine hesitancy versus uptake in seven Chinese megacities: a cross-sectional survey.Infectious diseases of poverty · 2026Article
- Addressing current limitations of household transmission studies by collecting contact data.American journal of epidemiology · 2024Article
- Global variability of influenza activity and virus subtype circulation from 2011 to 2023.BMJ open respiratory research · 2023Article
- Transmission dynamics of seasonal influenza in a remote island population.Scientific reports · 2023Article
- Indirect Protection from Vaccinating Children against Influenza A Virus Infection in Households.Viruses · 2022Article
- Effect of vaccine efficacy on disease transmission with age-structured.Chaos, solitons, and fractals · 2022Article
- Directly and Simultaneously Expressing Absolute and Relative Treatment Effects in Medical Data Models and Applications.Entropy (Basel, Switzerland) · 2021Article
- Effectiveness of Influenza Vaccines in the HIVE Household Cohort Over 8 Years: Is There Evidence of Indirect Protection?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Influenza vaccination: protecting the most vulnerable.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Association Between the Respiratory Microbiome and Susceptibility to Influenza Virus Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Influenza Vaccination: Effectiveness, Indications, and Limits in the Pediatric Population.Frontiers in pediatrics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized controlled trial, with one child in each household randomized to receive influenza vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy was 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members would only be reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.