ArticleNature communications2019
Iron-catalyzed carboazidation of alkenes and alkynes.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bimolecular Homolytic Substitution (SACS central science · 2025Review
- Iron-catalysed radical difunctionalization of alkenes.Nature synthesis · 2025Article
- Iron-catalyzed three-component 1,2-azidoalkylation of conjugated dienesChemical science · 2025Article
- Chemo-, regio-, and stereoselective tetrafunctionalization of fluoroalkynes enables divergent synthesis of 5-7-membered azacycles.Chemical science · 2024Article
- Recent advances in the application of alkynes in multicomponent reactions.RSC advances · 2024Review
- Coordinating activation strategy enables 1,2-alkylamidation of alkynes.Chemical science · 2023Article
- Iron-Catalyzed Synthesis of α-Azido α-Amino Esters via the Alkylazidation of Alkenes.Organic letters · 2023Article
- Radical 1,2,3-tricarbofunctionalization of α-vinyl-β-ketoesters enabled by a carbon shift from an all-carbon quaternary center.Chemical science · 2022Article
- Direct Metal-Free Transformation of Alkynes to Nitriles: Computational Evidence for the Precise Reaction Mechanism.International journal of molecular sciences · 2021Article
- Trifluoromethanesulfonyl azide as a bifunctional reagent for metal-free azidotrifluoromethylation of unactivated alkenes.Chemical science · 2021Article
- Iron-catalyzed domino coupling reactions of π-systems.Beilstein journal of organic chemistry · 2021Review
- Generation of Sulfonylated Tetrazoles through an Iron-Catalyzed Multicomponent Reaction Involving Sulfur Dioxide.iScience · 2020Article
- Article
- Revealing the Iron-Catalyzed β-Methyl Scission ofMolecules (Basel, Switzerland) · 2020Article
- Two-Step Azidoalkenylation of Terminal Alkenes Using Iodomethyl Sulfones.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carboazidation of alkenes and alkynes holds the promise to construct valuable molecules directly from chemical feedstock therefore is significantly important. Although a few examples have been developed, there are still some unsolved problems and lack of universal methods for carboazidation of both alkenes and alkynes. Here we describe an iron-catalyzed rapid carboazidation of alkenes and alkynes, enabled by the oxidative radical relay precursor t-butyl perbenzoate. This strategy enjoys success with a broad scope of alkenes under mild conditions, and it can also work with aryl alkynes which are challenging substrates for carboazidation. A large number of diverse structures, including many kinds of amino acid precursors, fluoroalkylated vinyl azides, other specific organoazides, and 2H-azirines can be easily produced.
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Registered trials
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