Evidence map›Paper›PMID 30630954›Full record

ArticleThe Journal of biological chemistry2019

Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation.

Fantao Meng, Tigist Kassa, Michael Brad Strader, Jayashree Soman, John S Olson, Abdu I Alayash

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Redox Potential (EMolecules (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease.Laboratory investigation; a journal of technical methods and pathology · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fantao MengFrom the Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 and.ORCID 0000-0003-2539-0589
Tigist KassaFrom the Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 and.
Michael Brad StraderFrom the Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 and.
Jayashree Somanthe BioSciences Department, Rice University, Houston, Texas 77251.
John S Olsonthe BioSciences Department, Rice University, Houston, Texas 77251.ORCID 0000-0002-0760-5403
Abdu I AlayashFrom the Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 and abdu.alayash@fda.hhs.gov.ORCID 0000-0002-2899-6757

Funding

Recombinant HbAp Production for In Vivo Toxicity StudiesP01HL110900 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRIEDMAN, JOEL M · 2012 to 2016
$10.6M
NHLBI NIH HHS P01 HL110900
6 · The paper itself

Abstract

After reacting with hydrogen peroxide (H

Indexed as

Anemia, Sickle CellHemoglobin, SickleHumansKineticsOxidation-ReductionProtein StabilityRecombinant ProteinsTemperatureTime FactorsHemoglobin, SickleRecombinant Proteinsgene therapyhemoglobinhypoxiamass spectrometry (MS)oxidation-reduction (redox)redox reactionssickle-cell disease

Identifiers

PMID30630954
PMCPMC6422104

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.