Evidence map›Paper›PMID 30630949›Full record

ArticleThe Journal of biological chemistry2019

Quantitative live-cell imaging and 3D modeling reveal critical functional features in the cytosolic complex of phagocyte NADPH oxidase.

Cornelia S Ziegler, Leïla Bouchab, Marc Tramier, Dominique Durand, Franck Fieschi, Sophie Dupré-Crochet, Fabienne Mérola, Oliver Nüße, Marie Erard

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
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  4. Article
  5. Lipoxin alleviates oxidative stress: a state-of-the-art review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  6. Review
  7. Review
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  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cornelia S ZieglerFrom the Laboratoire de Chimie Physique, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405, Orsay France.
Leïla BouchabFrom the Laboratoire de Chimie Physique, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405, Orsay France.
Marc Tramierthe Université Rennes, CNRS, Institut de Génétique et Développement de Rennes - UMR 6290, BIOSIT - UMS 3480, F-35000 Rennes, France.
Dominique Durandthe Institute for Integrative Biology of the Cell, CEA, CNRS UMR 9198, Université Paris-Sud, Université Paris-Saclay, 91190 Gif-sur-Yvette, France, and.
Franck Fieschithe Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, F-38044 Grenoble, France.
Sophie Dupré-CrochetFrom the Laboratoire de Chimie Physique, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405, Orsay France.
Fabienne MérolaFrom the Laboratoire de Chimie Physique, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405, Orsay France.
Oliver NüßeFrom the Laboratoire de Chimie Physique, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405, Orsay France, oliver.nusse@u-psud.fr.
Marie ErardFrom the Laboratoire de Chimie Physique, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405, Orsay France, marie.erard@u-psud.fr.ORCID 0000-0002-4063-365X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phagocyte NADPH oxidase produces superoxide anions, a precursor of reactive oxygen species (ROS) critical for host responses to microbial infections. However, uncontrolled ROS production contributes to inflammation, making NADPH oxidase a major drug target. It consists of two membranous (Nox2 and p22

Indexed as

Models, MolecularOptical ImagingAnimalsCells, CulturedCell SurvivalChlorocebus aethiopsComputer SimulationCOS CellsCytosolMicroscopy, FluorescenceNADPH OxidasesOxygenPhagocytesProtein ConformationNADPH OxidasesOxygenFCCSfluorescence correlation spectroscopy (FCS)fluorescence resonance energy transfer (FRET)fluorescent proteinFRET–FLIMintrinsically disordered proteinsNADPH oxidaseprotein complexprotein-protein interactionstructural model

Identifiers

PMID30630949
PMCPMC6422089

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.