Evidence map›Paper›PMID 30630942›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics.

Songye Li, Ming-Qiang Zheng, Mika Naganawa, Sujin Kim, Hong Gao, Michael Kapinos, David Labaree, Yiyun Huang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Optimization of a Nucleophilic Two-Step Radiosynthesis of 6-International journal of molecular sciences · 2023
    Article
  5. Article
  6. Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  7. Evaluation of (Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  8. Review
  9. Article
  10. Evaluation of Specific Binding of [ACS medicinal chemistry letters · 2021
    Article
  11. Kinetic Modeling and Test-Retest Reproducibility ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  12. Article
  13. A Survey of Molecular Imaging of Opioid Receptors.Molecules (Basel, Switzerland) · 2019
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Songye LiPET Center, Yale University School of Medicine, New Haven, Connecticut songye.li@yale.edu.
Ming-Qiang ZhengPET Center, Yale University School of Medicine, New Haven, Connecticut.
Mika NaganawaPET Center, Yale University School of Medicine, New Haven, Connecticut.
Sujin KimPET Center, Yale University School of Medicine, New Haven, Connecticut.
Hong GaoPET Center, Yale University School of Medicine, New Haven, Connecticut.
Michael KapinosPET Center, Yale University School of Medicine, New Haven, Connecticut.
David LabareePET Center, Yale University School of Medicine, New Haven, Connecticut.
Yiyun HuangPET Center, Yale University School of Medicine, New Haven, Connecticut.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Novel agonist tracers for PET imaging of kappa opioid receptorsR33MH092664 · NIMH · YALE UNIVERSITY · PI HUANG, YIYUN HENRY · 2013 to 2015
$2.0M
Novel agonist tracers for PET imaging of kappa opioid receptorsR21MH092664 · NIMH · YALE UNIVERSITY · PI HUANG, YIYUN HENRY · 2011 to 2012
$571k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R21 MH092664NIMH NIH HHS R33 MH092664
6 · The paper itself

Abstract

Studies have shown κ-opioid receptor (KOR) abnormalities in addictive disorders, other central nervous system diseases, and Alzheimer's disease. We have developed the first set of agonist

Indexed as

AnimalsMacaca mulattaPiperazinePiperazinesPositron-Emission TomographyRadioactive TracersRadiochemistryReceptors, Opioid, kappa11C-EKAPPiperazinePiperazinesRadioactive TracersReceptors, Opioid, kappa11C-EKAPagonistkappa opioid receptornonhuman primatesPET radiotracer

Identifiers

PMID30630942
PMCPMC6604690
OpenAlexW2909254081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.