ArticleScience (New York, N.Y.)2019
Emergence of preconfigured and plastic time-compressed sequences in early postnatal development.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Dual computational systems in the development and evolution of mammalian brains.Science advances · 2026Article
- Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit.Nature communications · 2026Article
- The Impact of Early-Life Seizures on the Maturation of Corticohippocampal Frequency Coordination.Journal of molecular neuroscience : MN · 2026Article
- Dynamical modulation of hippocampal replay through firing rate adaptation.Nature communications · 2026Article
- Preconfigured neuronal firing sequences in human brain organoids.Nature neuroscience · 2026Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Generative emergence of non-local representations in the hippocampus.Nature communications · 2025Article
- A sensitive period for the development of episodic-like memory in mice.Current biology : CB · 2025Article
- 40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Timing is everything: The effect of early-life seizures on developing neuronal circuits subserving spatial memory.Epilepsia open · 2025Review
- Sleep microstructure organizes memory replay.Nature · 2025Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Early and late place cells during postnatal development of the hippocampus.Nature communications · 2024Article
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
- Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies.Nature communications · 2024Article
- Nested compressed co-representations of multiple sequential experiences during sleep.Nature neuroscience · 2024Article
- Prefrontal cortical ripples mediate top-down suppression of hippocampal reactivation during sleep memory consolidation.Current biology : CB · 2024Article
- Infant neuroscience: how to measure brain activity in the youngest minds.Trends in neurosciences · 2024Review
17 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
When and how hippocampal neuronal ensembles first organize to support encoding and consolidation of memory episodes, a critical cognitive function of the brain, are unknown. We recorded electrophysiological activity from large ensembles of hippocampal neurons starting on the first day after eye opening as naïve rats navigated linear environments and slept. We found a gradual age-dependent, navigational experience-independent assembly of preconfigured trajectory-like sequences from persistent, location-depicting ensembles during postnatal week 3. Adult-like compressed binding of adjacent locations into trajectories during navigation and their navigational experience-dependent replay during sleep emerged in concert from spontaneous preconfigured sequences only during early postnatal week 4. Our findings reveal ethologically relevant distinct phases in the development of hippocampal preconfigured and experience-dependent sequential patterns thought to be important for episodic memory formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.