Evidence map›Paper›PMID 30630877›Full record

ArticleBioscience reports2019

Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes.

Sheida R Frolova, Vasili S Gorbunov, Natalia S Shubina, Alexander M Perepukhov, Sandaara G Romanova, Konstantin I Agladze

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sheida R FrolovaMoscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia.
Vasili S GorbunovMoscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia.
Natalia S ShubinaMoscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia.
Alexander M PerepukhovMoscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia.
Sandaara G RomanovaMoscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia.
Konstantin I AgladzeMoscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia agladze@yahoo.com.ORCID 0000-0002-9258-436X
Moscow Institute of Physics and Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substances that can be used as photosensitizers for cardiac tissue are very helpful in modeling various excitation patterns in a cardiac tissue culture and may have prospective use in the temporary and permanent ablation of unwanted excitation sources in the heart.The aim of the present work is to study the effect of stilbene derivative c-TAB (2- {4- [(E) -2- (4-ethoxyphenyl) vinyl] phenoxy} ethyl) trimethylammonium bromide) on the cardiomyocyte layers and voltage-gated ion channels in cardiac cells. C-TAB is a structural analog to AzoTAB, reported previously as a photoswitch for cardiac and neural cells, in which the azobenzene moiety is replaced by a stilbene grouping. Such a replacement makes c-TAB less toxic to living cells. c-TAB has been shown to successfully inhibit excitation in cardiac cells in both

Indexed as

Tissue Culture TechniquesAnimalsAnimals, NewbornHumansLightMyocytes, CardiacPhotosensitizing AgentsQuaternary Ammonium CompoundsRatsStilbenes4-azobenzenetrimethylammoniumPhotosensitizing AgentsQuaternary Ammonium CompoundsStilbenesExcitation wave propagationNeonatal rat cardiomyocyteStilbene derivativevoltage-gated channels

Identifiers

PMID30630877
PMCPMC6419148
OpenAlexW2910870359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.