ArticleSchizophrenia research2019
Disrupted modulation of thalamus activation and thalamocortical connectivity during dual task performance in schizophrenia.
Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia.bioRxiv : the preprint server for biology · 2026Article
- Prefronto-thalamic hypoconnectivity in schizophrenia: Monkey to human translation of critical pathways for symptom-related functions.PCN reports : psychiatry and clinical neurosciences · 2025Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
- Lifespan development of thalamic nuclei and characterizing thalamic nuclei abnormalities in schizophrenia using normative modeling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Unraveling multi-scale neuroimaging biomarkers and molecular foundations for schizophrenia: A combined multivariate pattern analysis and transcriptome-neuroimaging association study.CNS neuroscience & therapeutics · 2024Article
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- The impact of the human thalamus on brain-wide information processing.Nature reviews. Neuroscience · 2023Review
- Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients.Schizophrenia bulletin · 2023Article
- Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications.Biological psychiatry global open science · 2022Review
- Characterizing effects of age, sex and psychosis symptoms on thalamocortical functional connectivity in youth.NeuroImage · 2021Article
- Mediodorsal and Ventromedial Thalamus Engage Distinct L1 Circuits in the Prefrontal Cortex.Neuron · 2021Article
- Bridging the Gap? Altered Thalamocortical Connectivity in Psychotic and Psychedelic States.Frontiers in psychiatry · 2021Review
- Rostral Intralaminar Thalamus Engagement in Cognition and Behavior.Frontiers in behavioral neuroscience · 2021Review
- Dissociable contributions of mediodorsal and anterior thalamic nuclei in visual attentional performance: A comparison using nicotinic and muscarinic cholinergic receptor antagonists.Journal of psychopharmacology (Oxford, England) · 2020Article
- Thalamic Nuclei Volumes in Psychotic Disorders and in Youths With Psychosis Spectrum Symptoms.The American journal of psychiatry · 2020Article
- Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents.Frontiers in neural circuits · 2020Review
- NMDA Receptor Model of Antipsychotic Drug-Induced Hypofrontality.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Despite considerable evidence showing thalamus anatomy and connectivity abnormalities in schizophrenia, how these abnormalities are reflected in thalamus function during cognition is relatively understudied. Modulation of thalamic connectivity with the prefrontal cortex (PFC) is required for higher-order cognitive processes, which are often impaired in schizophrenia. To address this gap, we investigated how thalamus function and thalamus-PFC connectivity under different levels of cognitive demand may be disrupted in schizophrenia. Participants underwent fMRI scanning while performing an event-related two-alternative forced choice task under Single and Dual task conditions. In the Single task condition, participants responded either to a visual cue with a well-learned motor response, or an audio cue with a well-learned vocal response. In the Dual task condition, participants performed both tasks. Thalamic connectivity with task relevant regions of the PFC for each condition was measured using beta-series correlation. Individuals with schizophrenia demonstrated less modulation of both mediodorsal thalamus activation and thalamus-PFC connectivity with increased cognitive demand. In contrast, their ability to modulate PFC function during task performance was maintained. These results suggest that the pathophysiology of cognitive impairment in schizophrenia is associated with thalamus-PFC circuitry and suggests that the thalamus, along with the PFC, should be a focus of investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.