ArticleCritical care (London, England)2019
Early diuretic use and mortality in critically ill patients with vasopressor support: a propensity score-matching analysis.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Restrictive resuscitation in patients with sepsis and mortality: A systematic review and meta-analysis with trial sequential analysis.Pharmacotherapy · 2023Pooled it
- Association of thiamine supplementation with 30-day mortality among ICU patients with sepsis-associated delirium.Scientific reports · 2026Article
- Impact of infection on decongestion and kidney outcomes in patients with cardiorenal syndrome type 1.PloS one · 2026Article
- The association between family history of hypertension and diabetic kidney disease in patients with diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Acetaminophen is associated with improved survival in critically ill lung cancer patients: A propensity score-matched cohort study.International journal of medical sciences · 2026Article
- The potential effectiveness of tolvaptan in critically ill patients including cardiac and noncardiac populations: a retrospective observational study.Naunyn-Schmiedeberg's archives of pharmacology · 2025Observational
- Prognostic impact of early versus delayed loop diuretic administration in sepsis: a propensity score-matched analysis using the MIMIC-IV database.Translational andrology and urology · 2025Article
- Association between metabolic dysfunction associated steatotic liver disease and gallstones in the US population using propensity score matching.Scientific reports · 2025Article
- Impact of in-hospital body mass index variation on 28-day mortality in critically ill surgical patients: a multi-center retrospective analysis.Frontiers in medicine · 2025Article
- Fluid accumulation syndrome in sepsis and septic shock: pathophysiology, relevance and treatment-a comprehensive review.Annals of intensive care · 2024Review
- Article
- Clinical Features of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Induced by Immune Checkpoint Inhibitor versus Non-Immune Checkpoint Inhibitor Drugs in China: A Cross-Sectional Study and Literature Review.Journal of inflammation research · 2024Article
- Association between functional constipation and vaginal wind in women at 6 weeks postpartum.International urogynecology journal · 2023Article
- Observational
- Impact of Negative Fluid Balance on Mortality and Outcome of Patients with Confirmed COVID-19.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Association between Wait Time for Transthoracic Echocardiography and 28-Day Mortality in Patients with Septic Shock: A Cohort Study.Journal of clinical medicine · 2022Article
- Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis.Annals of intensive care · 2022Review
- Early Diuretics for De-resuscitation in Septic Patients With Left Ventricular Dysfunction.Clinical Medicine Insights. Cardiology · 2022Article
- A Positive Fluid Balance in the First Week Was Associated With Increased Long-Term Mortality in Critically Ill Patients: A Retrospective Cohort Study.Frontiers in medicine · 2022Article
- Nordic survey on assessment and treatment of fluid overload in intensive care.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of loop diuretic use in critically ill patients on vasopressor support or in shock is unclear. This study aimed to explore the relationship between loop diuretic use and hospital mortality in critically ill patients with vasopressor support.
methodsData were extracted from the Medical Information Mart for Intensive Care III database. Adult patients with records of vasopressor use within 48 h after intensive care unit admission were screened. Multivariable logistic regression and propensity score matching was used to investigate any association.
resultsData on 7828 patients were included. The crude hospital mortality was significantly lower in patients with diuretic use (166/1469 vs. 1171/6359, p < 0.001). In the extended multivariable logistic models, the odds ratio (OR) of diuretic use was consistently significant in all six models (OR range 0.56-0.75, p < 0.05 for all). In the subgroup analysis, an interaction effect was detected between diuretic use and fluid balance (FB). In the positive FB subgroup, diuretic use was significantly associated with decreased mortality (OR 0.64, 95% confidence interval (CI) 0.51-0.78) but was insignificant in the negative FB subgroup. In the other subgroups of mean arterial pressure, maximum sequential organ failure assessment score, and lactate level, the association between diuretic use and mortality remained significant and no interaction was detected. After propensity score matching, 1463 cases from each group were well matched. The mortality remained significantly lower in the diuretic use group (165/1463 vs. 231/1463, p < 0.001).
conclusionsAlthough residual confounding cannot be excluded, loop diuretic use is associated with lower mortality.
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