ArticleBMC gastroenterology2019
Risk factors and long-term outcome of disease extent progression in Asian patients with ulcerative colitis: a retrospective cohort study.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics.Chronic diseases and translational medicine · 2025Article
- Progressing or preserving, disease extent evolution in hospitalized patients with ulcerative colitis in China: a real-world study.Therapeutic advances in gastroenterology · 2025Article
- Investigating the impact of steroid dependence on gastrointestinal surgical outcomes from UK Biobank.Scientific reports · 2024Article
- Changes in the clinical course and prognosis of ulcerative colitis in Chinese populations: a retrospective cohort study.Intestinal research · 2024Article
- Low Adherence is Associated with Chronic Active Disease in Ulcerative Colitis: A Retrospective Study from a Single Referral Center.Patient preference and adherence · 2023Article
- Propensity score analysis the clinical characteristics of active distal and extensive ulcerative colitis: a retrospective study.Frontiers in physiology · 2023Article
- How has the disease course of pediatric ulcerative colitis changed throughout the biologics era? A comparison with the IBSEN study.World journal of gastroenterology · 2022Article
- Factors Predictive of Proximal Disease Extension and Clinical Course of Patients Initially Diagnosed with Ulcerative Proctitis in an IBD Referral Center.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Time-adjusted average Mayo endoscopic score predicts the risk of disease extent progression in distal ulcerative colitis patients.Gastroenterology report · 2022Article
- Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension.Gastroenterology · 2021Article
- Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User's Guide for Adult and Pediatric Gastroenterologists.Gastroenterology · 2021Review
- The Degree of Ulcerative Colitis Burden of Luminal Inflammation score is superior to predicting medium- to long-term prognosis in patients with active ulcerative colitis.Therapeutic advances in gastroenterology · 2020Article
- Dietary Supplementation with Sea Bass (International journal of molecular sciences · 2019Article
- [Current Strategies in the Diagnosis and Follow-up of Inflammatory Bowel Diseases].Acta gastroenterologica LatinoamericanaReview
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of Ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. The aim of this study was to identify risk factors predictive of extent progression in Asian patients with UC and to evaluate the clinical outcome by longitudinal follow-up.
methodsWe retrospectively analyzed 518 UC patients without ascending colon involvement at diagnosis who were regularly followed and underwent colonoscopy between 2003 and 2016 in an Asian tertiary referral center. Proximal disease extension and associated risk factors were analyzed.
resultsA total of 91 (17.6%) patients experienced proximal disease extension followed for a median period of 7.5 years. The median time for extent extension was 16.1 months (interquartile range (IQR) 8.3-42.2). The cumulative rate of disease extension was 9.9, 14.9, 19.6, 24.6 and 30.5% at 1,2,3,4 and 5 years after diagnosis. 43 (12.0%) patients with E1/E2 progressed to E3, and 40 (21.9%) with E1 progressed to E2. Of patients diagnosed with E3 involvement limited to the hepatic flexure distally, 8 (13.3%) progressed to pancolitis. Cox regression analysis found that disease extent at diagnosis was the sole predictor of disease extension (odds ratio (OR),1.74, 95% confidence interval (CI) 1.18-2.57, p = 0.01). Proximal disease extension was associated with disease relapse (p = 0.03) and increased use of steroids and immunosuppressive agents (p < 0.01).
conclusionUC is a dynamic disease and that the disease extension in Asians was comparable to that in Caucasians. Proximal disease extension increased the risk of disease flare and treatment intensification.
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