Evidence map›Paper›PMID 30630301›Full record

ArticleAnnals of coloproctology2018

Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer.

Kwangmin Kim, Ernes John T Castro, Hongjin Shim, John Vincent G Advincula, Young-Wan Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of coloproctology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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  15. Genetic heterogeneity of colorectal cancer and the microbiome.World journal of gastrointestinal oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kwangmin KimBig Data Research Group, Yonsei University Wonju College of Medicine, Wonju, Korea.
Ernes John T CastroDepartment of Surgery, The Medical City, Pasig, Philippines.
Hongjin ShimDivision of Trauma Surgery and Surgical Critical Care, Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
John Vincent G AdvinculaDepartment of Surgery, Amang Memorial Rodriguez Medical Center, Marikina City, Philippines.
Young-Wan KimBig Data Research Group, Yonsei University Wonju College of Medicine, Wonju, Korea.

Funding

National Research Foundation of Korea 2017R1D1A3B03032301
6 · The paper itself

Abstract

For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

Indexed as

Colonic neoplasmsGastrointestinal microbiomeMolecular subtypeTreatment outcome

Identifiers

PMID30630301
PMCPMC6347335

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.