Evidence map›Paper›PMID 30630168›Full record

ArticleDementia and geriatric cognitive disorders2019

Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases.

Alice Y Hua, Jenna L Wells, Claudia M Haase, Kuan-Hua Chen, Howard J Rosen, Bruce L Miller, Robert W Levenson

Open access · greenAbstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Interpersonal linkage in positive and negative emotional behaviors, emotional well-being, and physical functioning in dementia caregivers.Clinical psychological science : a journal of the Association for Psychological Science · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. BioMed research international · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alice Y HuaDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.
Jenna L WellsDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.
Claudia M HaaseSchool of Education and Social Policy, Northwestern University, Evanston, Illinois, USA.
Kuan-Hua ChenDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.
Howard J RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Robert W LevensonDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA, boblev@berkeley.edu.
University of California, Berkeley · USUniversity of California, San Francisco · USNorthwestern University · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PREDOCTORAL TRAINING CONSORTIUM IN AFFECTIVE SCIENCET32MH020006 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI GROSS, JAMES J, JOHNSON, SHERI L · 1998 to 2018
$5.9M
Predicting Risk for Adverse Outcomes in Dementia CaregiversR01AG062639 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Casey Leigh Brown, Robert Wayne Levenson · 2019 to 2026
$4.8M
Developing and Evaluating In-Home Supportive Technology for Dementia CaregiversR44AG059458 · NIA · PEOPLE POWER COMPANY · PI WANG, GENE · 2018 to 2020
$4.7M
EMOTION AND AGE--REACTION, REGULATION AND UNDERSTANDINGR37AG017766 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVENSON, ROBERT WAYNE · 2000 to 2009
$3.7M
Commercializing In-Home Supportive Technolgy for Dementia CaregiversSB1AG059458 · NIA · PEOPLE POWER COMPANY · PI WANG, GENE · 2021 to 2022
$3.2M
Burden, Depression, and Health in Dementia Caregivers: The Role of EmotionR01AG041762 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVENSON, ROBERT WAYNE · 2012 to 2016
$2.8M
Burden, Depression, and Health in Dementia Caregivers: The Role of EmotionR56AG041762 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVENSON, ROBERT WAYNE · 2018 to 2018
$725k
Behavioral and physiological linkage in people with frontotemporal dementia and spousal caregiversK99AG059947 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, KUAN-HUA · 2019 to 2021
$335k
NIA NIH HHS K99 AG059947NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG041762NIA NIH HHS R01 AG062639NIA NIH HHS R37 AG017766NIA NIH HHS R44 AG059458NIA NIH HHS R56 AG041762NIA NIH HHS SB1 AG059458NIMH NIH HHS T32 MH020006
6 · The paper itself

Abstract

backgroundCaregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound.

aimsTo determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship.

methodsIn 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and patient behavior and cognitive symptoms.

resultsPatient atrophy in the right insula and medial frontal gyrus was associated with worse caregiver health; this relationship was partially mediated by patient neuropsychiatric symptoms, and assessing atrophy in these regions improved predictions of poor caregiver health above and beyond patient behavioral symptoms.

conclusionsThis study shows the value of patients' brain data in identifying caregivers at risk for becoming sick themselves.

Indexed as

CaregiversCerebral CortexAgedAtrophyBehavioral SymptomsFemaleHealth Status DisparitiesHumansMagnetic Resonance ImagingMaleMiddle AgedNeurodegenerative DiseasesOrgan SizePreventive Health ServicesRisk AssessmentCaregiver healthNeurodegenerative diseasePatient behavioral symptomsPatient cognitive symptomsVoxel-based morphometry

Identifiers

PMID30630168
PMCPMC6568322
OpenAlexW2909940796

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.