Evidence map›Paper›PMID 30630085›Full record

Observational studyJournal of the American College of Surgeons2019

How Durable Is Total Pancreatectomy and Intraportal Islet Cell Transplantation for Treatment of Chronic Pancreatitis?

Melena D Bellin, Gregory J Beilman, David Er Sutherland, Hawa Ali, Arzu Petersen, Steven Mongin, Varvara Kirchner, Sarah J Schwarzenberg, Guru Trikudanathan, Martin L Freeman and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American College of Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 102 citations in OpenAlex.

  1. Trial
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  9. Observational
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  11. 16. Pain in chronic pancreatitis.Pain practice : the official journal of World Institute of Pain · 2025
    Review
  12. Surgical management of chronic pancreatitis: A narrative review.United European gastroenterology journal · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Melena D BellinDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.
Gregory J BeilmanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
David Er SutherlandDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN; Schulze Diabetes Institute, University of Minnesota Medical School, Minneapolis, MN.
Hawa AliDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Arzu PetersenDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Steven MonginBiostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN.
Varvara KirchnerDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Sarah J SchwarzenbergDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.
Guru TrikudanathanDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Martin L FreemanDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Timothy L PruettDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Srinath ChinnakotlaDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. Electronic address: chinni@umn.edu.
University of Minnesota Medical Center · US

Funding

Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

backgroundA total pancreatectomy and intraportal islet cell autotransplant (TPIAT) is increasingly being offered to patients with chronic pancreatitis (CP). The benefits include removal of the root cause of pain and amelioration of diabetes. However, the long-term durability of this operation remains unclear. STUDY

designOf the 742 patients who have undergone a TPIAT at our center, 215 who did so between 1998 and 2008 now have at least 10 years of follow-up time and were eligible for this single-center observational study. Our outcomes measures included abdominal pain relief, narcotic use, islet graft function (subdivided into 3 groups: insulin independence; partial graft function, defined by C-peptide level > 0.6 mg/dL; and no function, defined by C-peptide level < 0.6 mg/dL), and health-related quality of life.

resultsThe 10-year actuarial survival rate was 72%. A BMI > 30 kg/m

conclusionsThis represents the first and largest series to examine long-term outcomes (10 years or more) in TPIAT patients. In our series, this dual procedure produced durable pain relief and sustained islet graft function, even past 10 years postoperatively.

Indexed as

AdolescentAdultAgedChildFemaleFollow-Up StudiesHumansIslets of Langerhans TransplantationLogistic ModelsMaleMiddle AgedPain MeasurementPancreatectomyPancreatitis, ChronicQuality of LifeSurvival Analysis

Identifiers

PMID30630085
PMCPMC8579321
OpenAlexW2908864925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.