Evidence map›Paper›PMID 30629937›Full record

ArticleStem cell reports2019

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs.

Anil Belur Nagaraj, Peronne Joseph, Erin Ponting, Yuriy Fedorov, Salendra Singh, Alex Cole, Woncheol Lee, Euisik Yoon, Alessia Baccarini, Peter Scacheri and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Expert opinion on therapeutic targets · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Anil Belur NagarajCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Peronne JosephCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Erin PontingCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Yuriy FedorovSmall Molecules Drug Development Core Facility, Office of Research Administration, Case Western Reserve University, Cleveland, OH 44106, USA.
Salendra SinghCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Alex ColeDepartment of Electrical Engineering and Computer Science, Center for Wireless Integrated MicroSensing and Systems (WIMS2), The University of Michigan, Ann Arbor, MI, USA.
Woncheol LeeDepartment of Electrical Engineering and Computer Science, Center for Wireless Integrated MicroSensing and Systems (WIMS2), The University of Michigan, Ann Arbor, MI, USA.
Euisik YoonDepartment of Electrical Engineering and Computer Science, Center for Wireless Integrated MicroSensing and Systems (WIMS2), The University of Michigan, Ann Arbor, MI, USA.
Alessia BaccariniDepartment of Genetics and Multiscale Biology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Peter ScacheriDepartment of Genetics and Genomic Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Ronald BuckanovichDepartment of Medicine, Magee Women's Cancer Research Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Drew J AdamsSmall Molecules Drug Development Core Facility, Office of Research Administration, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Genetics and Genomic Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Ronny DrapkinPenn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Brian D BrownDepartment of Genetics and Multiscale Biology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Analisa DiFeoRogel Cancer Center, The University of Michigan, Michigan Medicine, Ann Arbor, MI, USA; Department of Obstetrics and Gynecology, The University of Michigan, Michigan Medicine, Ann Arbor, MI, USA; Department of Pathology, The University of Michigan, Michigan Medicine, Ann Arbor, MI, USA. Electronic address: adifeo@med.umich.edu.
Case Western Reserve University · USUniversity of Michigan–Ann Arbor · USIcahn School of Medicine at Mount Sinai · USCancer Research Center · USMichigan Medicine · USUPMC Hillman Cancer Center · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B., ODUNSI, KUNLE · 2013 to 2025
$19.6M
GRADUATE TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM008056 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI DIEHL, JOHN ALAN, SNIDER, MARTIN D · 1985 to 2019
$7.1M
Examining the role of the miR-181a:Wnt/B-catenin axis in ovarian cancerR01CA197780 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Analisa Virginia DiFeo · 2016 to 2026
$3.3M
NCI NIH HHS P30 CA043703NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA197780NIGMS NIH HHS T32 GM008056
6 · The paper itself

Abstract

Tumor-initiating cells (TICs) contribute to drug resistance and tumor recurrence in cancers, thus experimental approaches to dissect the complexity of TICs are required to design successful TIC therapeutic strategies. Here, we show that miRNA-3' UTR sensor vectors can be used as a pathway-based method to identify, enrich, and analyze TICs from primary solid tumor patient samples. We have found that an miR-181a

Indexed as

3' Untranslated RegionsAntineoplastic AgentsBiosensing TechniquesCell Line, TumorDrug DiscoveryFemaleHumansMicroRNAsNeoplastic Stem CellsOvarian Neoplasms3' Untranslated RegionsAntineoplastic AgentsMicroRNAsBET inhibitorsmiR-181amiRNA sensorovarian cancertumor heterogeneitytumor-initiating cells

Identifiers

PMID30629937
PMCPMC6335585
OpenAlexW2909189324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.