ArticlePloS one2019
Comparative transcriptome analysis reveals osmotic-regulated genes in the gill of Chinese mitten crab (Eriocheir sinensis).
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Deciphering the molecular landscape of hepatopancreatic necrosis disease in Eriocheir sinensis using RNA-Seq meta-analysis.Genes & genomics · 2026Pooled it
- Population structure and genome-wide adaptive differentiation of wild Chinese mitten crab (Eriocheir sinensis) across river basins in China.BMC genomics · 2026Article
- Physiological and Transcriptome Analyses Offer Insights into Revealing the Mechanisms of Red Tilapia (Antioxidants (Basel, Switzerland) · 2025Article
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- Analysis of adaptive molecular mechanisms in response to low salinity in antennal gland of mud crab,Heliyon · 2024Article
- Ionic regulatory strategies of crabs: the transition from water to land.Frontiers in physiology · 2024Review
- Comparative Transcriptome Analysis of the Response toBiology · 2023Article
- Regulation Mechanism of Dopamine Receptor 1 in Low Temperature Response ofInternational journal of molecular sciences · 2023Article
- Transcriptome and molecular regulatory mechanisms analysis of gills in the black tiger shrimpFrontiers in physiology · 2023Article
- Comparative Transcriptome Analysis ofLife (Basel, Switzerland) · 2022Article
- Salinity-Driven Changes in Behavioral Responses of CatadromousAnimals : an open access journal from MDPI · 2022Article
- Transcriptome Analysis to Study the Molecular Response in the Gill and Hepatopancreas Tissues ofFrontiers in physiology · 2022Article
- A Multi-Species Comparison and Evolutionary Perspectives on Ion Regulation in the Antennal Gland of Brachyurans.Frontiers in physiology · 2022Review
- Mechanisms of NaFrontiers in physiology · 2022Review
- Differential Expression of the Apolipoprotein AI Gene in Spotnape Ponyfish (International journal of environmental research and public health · 2021Article
- Physiological plasticity and acclimatory responses to salinity stress are ion-specific in the mayfly, Neocloeon triangulifer.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Identification of putative ingestion-related olfactory receptor genes in the Chinese mitten crab (Eriocheir japonica sinensis).Genes & genomics · 2021Article
- Toxic effects of metal copper stress on immunity, metabolism and pathologic changes in Chinese mitten crab (Eriocheir japonica sinensis).Ecotoxicology (London, England) · 2021Article
- Role of Transportome in the Gills of Chinese Mitten Crabs in Response to Salinity Change: A Meta-Analysis of RNA-Seq Datasets.Biology · 2021Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salinity is one of the most important abiotic factors directly affecting the reproduction, molting, growth, immune, physiological and metabolic activities of Chinese mitten crab (Eriocheir sinensis). This species has strong osmoregulatory capacity and can maintain stringent internal homeostasis. However, the mechanisms conferring tolerance to salinity fluctuations are not well understood. To reveal the genes and pathways involved in osmoregulation, adult male crabs (body weight = 110 ± 5 g) were acclimated for 144 h in freshwater (FW, 0 ppt) or seawater (SW, 25 ppt). Changes in the transcriptome of crab gills were then analysed by RNA-Seq, and 174,903 unigenes were obtained. Comparison of genes between FW- SW-acclimated groups identified 932 genes that were significantly differentially expressed in the gill, comprising 433 and 499 up- and downregulated transcripts. Gene Ontology functional enrichment analysis revealed that important biological processes related to salt stress were significantly enriched, including energy metabolism, ion transport, signal transduction and antioxidant activity. Kyoto Encyclopaedia of Genes and Genomes enrichment analysis mapped the differentially expressed genes to 241 specific metabolic pathways, and pathways related to energy metabolism, oxidative phosphorylation and the tricarboxylic acid (TCA)/citrate cycle were significantly enriched. Salinity stress altered the expression of many enzymes involved in energy metabolism, ion transport, signal transduction and antioxidant pathways, including citrate synthase (CS), Na+/K+-ATPase (NKA), Na+-K+-2Cl cotransporter-1 (NKCC1), dopamine receptor D1 (DRD1), synaptic binding protein 1 (STXBP1), Cu2+/Zn2+ superoxide dismutase (SOD1) and glutathione S-transferase (GST). Additionally, the obtained transcriptomic sequencing data provided a useful resource for identification of novel genes, and further physiological analysis of Chinese mitten crab.
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